Epithelial ovarian cancer (EOC) represents the most frequent cause of death in the United
States from a cancer involving the female genital tract. Contributing to the overall poor …

Various research fields use the transfection of mammalian cells with genetic material to
induce the expression of a target transgene or gene silencing. It is a tool widely used in …

Cardiotonic steroids (such as ouabain) signaling through Na/K-ATPase regulate sodium
reabsorption in the renal proximal tubule. We report here that reactive oxygen species are …

A major characteristic of prostate cancer is the elevation of serum levels of prostate-specific
antigen (hK3) and hK2, which are tumor markers that correlate with advancing stages of …

The conventional approach to investigate genotype–phenotype relationships has been the
generation of gene targeted murine strains. However, the emergence of RNAi technologies …

Protease activated receptors (PARs) populate neurons and astrocytes in the brain. The
serine protease thrombin, which activates PAR-1 during the first hours after stroke, appears …

Background We have demonstrated that cardiotonic steroids, such as ouabain, signaling
through the Na/K‐ATP ase, regulate sodium reabsorption in the renal proximal tubule. By …

Actin is a central mediator of the chondrocyte phenotype. Monolayer expansion of articular
chondrocytes on tissue culture polystyrene, for cell-based repair therapies, leads to …

In spinal cord injury, glial scarring, a result of overexpressed intermediate filament (IF)
proteins including glial fibrillary acidic protein (GFAP) and vimentin, is one of the largest …

MYC levels are tightly regulated in cells, and deregulation is associated with many cancers.
In this report, we describe the existence of a MYC-protein kinase A (PKA)-polo-like kinase 1 …