An overview of triple-negative breast cancer

P Kumar, R Aggarwal - Archives of gynecology and obstetrics, 2016 - Springer
Purpose Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors
comprising various breast cancers simply defined by the absence of estrogen receptor …

Prognostic value of different cut-off levels of Ki-67 in breast cancer: a systematic review and meta-analysis of 64,196 patients

F Petrelli, G Viale, M Cabiddu, S Barni - Breast cancer research and …, 2015 - Springer
A proliferative marker, expressed as the percentage of cells in a cell cycle, has been
developed and used as a discriminant of more aggressive malignant phenotypes in early …

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

G Bianchini, JM Balko, IA Mayer, ME Sanders… - Nature reviews Clinical …, 2016 - nature.com
Chemotherapy is the primary established systemic treatment for patients with triple-negative
breast cancer (TNBC) in both the early and advanced-stages of the disease. The lack of …

Triple‐negative breast cancer: an unmet medical need

CA Hudis, L Gianni - The oncologist, 2011 - academic.oup.com
Triple‐negative breast cancer, characterized by tumors that do not express estrogen
receptor (ER), progesterone receptor (PR), or HER‐2 genes, represents an important clinical …

[HTML][HTML] Triple-negative breast cancer—current status and future directions

O Gluz, C Liedtke, N Gottschalk, L Pusztai, U Nitz… - Annals of …, 2009 - Elsevier
Triple-negative breast cancer (TNBC) is defined by a lack of expression of both estrogen
and progesterone receptor as well as human epidermal growth factor receptor 2. It is …

Triple-negative breast cancer: role of specific chemotherapy agents

SJ Isakoff - The Cancer Journal, 2010 - journals.lww.com
Cytotoxic chemotherapy remains the mainstay of treatment for triple-negative breast cancer
(TNBC) despite the promise of new targeted and biologic agents. Many studies have shown …

[HTML][HTML] Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast …

BK Linderholm, H Hellborg, U Johansson… - Annals of oncology, 2009 - Elsevier
Background Triple-negative breast cancer (TNBC) lacking expression of steroid receptors
and human epidermal growth factor receptor 2, having chemotherapy as the only …

[HTML][HTML] How shall we treat early triple-negative breast cancer (TNBC): from the current standard to upcoming immuno-molecular strategies

JH Park, JH Ahn, SB Kim - ESMO open, 2018 - Elsevier
Triple-negative breast cancer (TNBC) is a long-lasting orphan disease in terms of little
therapeutic progress during the past several decades and still the standard of care remains …

Triple-negative breast cancer: who should receive neoadjuvant chemotherapy?

LN Chaudhary, KH Wilkinson… - Surgical Oncology …, 2018 - surgonc.theclinics.com
With advances in genetic studies, breast cancer has been identified as a heterogeneous
disease with distinct subtypes that respond variably to different therapies. The concept of …

DNA Damage Inducer Mitoxantrone Amplifies Synergistic Mild‐Photothermal Chemotherapy for TNBC via Decreasing Heat Shock Protein 70 Expression

Z Chen, S Li, F Li, C Qin, X Li, G Qing… - Advanced …, 2023 - Wiley Online Library
Patients with triple‐negative breast cancer (TNBC) have the worst clinical outcomes when
compared to other subtypes of breast cancer. Nanotechnology‐assisted photothermal …