A field guide to foldamers

DJ Hill, MJ Mio, RB Prince, TS Hughes… - Chemical …, 2001 - ACS Publications
The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

β-Peptides: from structure to function

RP Cheng, SH Gellman, WF DeGrado - Chemical reviews, 2001 - ACS Publications
In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

Carbohydrate-based mimetics in drug design: sugar amino acids and carbohydrate scaffolds

SAW Gruner, E Locardi, E Lohof, H Kessler - Chemical reviews, 2002 - ACS Publications
Among the major classes of biomolecules, carbohydrates allow almost unlimited structural
variations. The molecular diversity of carbohydrates offers a valuable tool for drug discovery …

De novo design, synthesis, and characterization of antimicrobial β-peptides

D Liu, WF DeGrado - Journal of the American Chemical Society, 2001 - ACS Publications
β-Peptides are a class of polyamides that have been demonstrated to adopt a variety of
helical conformations. Recently, a series of amphiphilic L+ 2 helical β-peptides were …

[PDF][PDF] Design of Secondary Structures in Unnatural Peptides: Stable Helical gamma-Tetra-Hexa-, and Octapeptides and Consequences of -Substitution

S Hanessian, X Luo, R Schaum… - JOURNAL-AMERICAN …, 1998 - researchgate.net
The secondary structures of oligomeric organic molecules are known to reveal fascinating
architectures that can be responsible for their aesthetic beauty as well as their biological …

Hollow crescents, helices, and macrocycles from enforced folding and folding-assisted macrocyclization

B Gong - Accounts of chemical research, 2008 - ACS Publications
This Account reviews the progress made by us on creating porous molecular crescents,
helices, and macrocycles based on aromatic oligoamides. Inspired by natural pore-or cavity …

[图书][B] Glycoscience: chemistry and chemical biology I–III

BO Fraser-Reid, K Tatsuta, J Thiem - 2002 - books.google.com
Glycostructures play a highly diverse and crucial role in a myriad of organisms and important
systems in biology, physiology, medicine, bioengineering and technology. Only in recent …

Synthesis and Structural Characterization of Helix-Forming β-Peptides:  trans-2-Aminocyclopentanecarboxylic Acid Oligomers

DH Appella, LA Christianson, DA Klein… - Journal of the …, 1999 - ACS Publications
Synthetic protocols and circular dichroism (CD) spectra are reported for a series of
oligomers of (R, R)-trans-2-aminocyclopentanecarboxylic acid (trans-ACPC). The two …

Hydrogen bonded oligohydrazide foldamers and their recognition for saccharides

JL Hou, XB Shao, GJ Chen, YX Zhou… - Journal of the …, 2004 - ACS Publications
This paper describes the synthesis and characterization of the first series of hydrogen
bonding-driven hydrazide foldamers and their recognition for alkyl saccharides in …

Synthesis and Characterization of trans-2-Aminocyclohexanecarboxylic Acid Oligomers:  An Unnatural Helical Secondary Structure and Implications for β-Peptide …

DH Appella, LA Christianson, IL Karle… - Journal of the …, 1999 - ACS Publications
The preparation, crystal structures, and circular dichroism (CD) spectra of two oligomers of
optically active trans-2-aminocyclohexanecarboxylic acid are reported. In the solid state …