Activated fibroblasts in cancer: Perspectives and challenges

G Caligiuri, DA Tuveson - Cancer cell, 2023 - cell.com
Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Wound healing, fibroblast heterogeneity, and fibrosis

HE Talbott, S Mascharak, M Griffin, DC Wan… - Cell stem cell, 2022 - cell.com
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

[HTML][HTML] Fibroblasts: Origins, definitions, and functions in health and disease

MV Plikus, X Wang, S Sinha, E Forte, SM Thompson… - Cell, 2021 - cell.com
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Screening cell–cell communication in spatial transcriptomics via collective optimal transport

Z Cang, Y Zhao, AA Almet, A Stabell, R Ramos… - Nature …, 2023 - nature.com
Spatial transcriptomic technologies and spatially annotated single-cell RNA sequencing
datasets provide unprecedented opportunities to dissect cell–cell communication (CCC) …

Inference and analysis of cell-cell communication using CellChat

S Jin, CF Guerrero-Juarez, L Zhang, I Chang… - Nature …, 2021 - nature.com
Understanding global communications among cells requires accurate representation of cell-
cell signaling links and effective systems-level analyses of those links. We construct a …

All‐in‐one: multifunctional hydrogel accelerates oxidative diabetic wound healing through timed‐release of exosome and fibroblast growth factor

Y Xiong, L Chen, P Liu, T Yu, C Lin, C Yan, Y Hu… - Small, 2022 - Wiley Online Library
The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic
wounds characterized by multiple drug‐resistant bacterial infections, angiopathy, and …

The role of myofibroblasts in physiological and pathological tissue repair

R Schuster, F Younesi, M Ezzo… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Identification, discrimination and heterogeneity of fibroblasts

U Lendahl, L Muhl, C Betsholtz - Nature communications, 2022 - nature.com
Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

[HTML][HTML] Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer

S Sinha, HD Sparks, E Labit, HN Robbins, K Gowing… - Cell, 2022 - cell.com
Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …

[HTML][HTML] Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing

S Mascharak, HE Talbott, M Januszyk, M Griffin… - Cell Stem Cell, 2022 - cell.com
Regeneration is the holy grail of tissue repair, but skin injury typically yields fibrotic, non-
functional scars. Developing pro-regenerative therapies requires rigorous understanding of …