Terrestrial organisms developed circadian rhythms for adaptation to Earth's quasi-24-h
rotation. Achieving precise rhythms requires diurnal oscillation of fundamental biological …

New approaches are needed to treat people whose obesity and type 2 diabetes (T2D) are
driven by specific mechanisms. We investigate a deletion on chromosome 16p11. 2 …

Abstract Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited
neurodegenerative disease caused by CAG repeat expansion in the first coding exon of the …

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset
cerebellar ataxia caused by mutations in SACS, which encodes the protein sacsin. Cellular …

Large polyglutamine expansions in Ataxin-2 (ATXN2) cause multi-system nervous atrophy in
Spinocerebellar Ataxia type 2 (SCA2). Intermediate size expansions carry a risk for selective …

Diabetic peripheral neuropathy (DPN) is a chronic complication associated with nerve
dysfunction and uncontrolled hyperglycemia. Unfortunately, due to its complicated etiology …

Polyglutamine (polyQ) spinocerebellar ataxias (SCAs) comprise a group of autosomal
dominant neurodegenerative disorders caused by (CAG/CAA) n expansions. The elongated …

Senescence-accelerated mouse prone 8 (SAMP8) mice exhibit cognitive defects and
neuron loss with aging, and were used to study anti-aging effects of Dendrobium nobile …

Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2
(ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control …

Human T-cell lymphotropic virus type 1 (HTLV-1) infection affects millions of individuals
worldwide and can lead to severe leukemia, myelopathy/tropical spastic paraparesis, and …