Contemporary medical, device, and surgical therapies for obesity in adults

CM Perdomo, RV Cohen, P Sumithran, K Clément… - The Lancet, 2023 - thelancet.com
The goal of obesity management is to improve health. Sustained weight loss of more than
10% overall bodyweight improves many of the complications associated with obesity (eg …

[HTML][HTML] Pharmacotherapy of obesity: an update on the available medications and drugs under investigation

M Chakhtoura, R Haber, M Ghezzawi, C Rhayem… - …, 2023 - thelancet.com
Obesity is an epidemic and a public health threat. Medical weight management remains one
of the options for the treatment of excess weight and recent advances have revolutionized …

A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic …

C Boutari, CS Mantzoros - Metabolism, 2022 - Elsevier
The WHO just released in May 2022 a report on the state of the obesity pandemic in Europe,
stating that 60% of citizens in the area of Europe are either overweight or obese, and …

New insights into the treatment of obesity

M Blüher, M Aras, LJ Aronne… - Diabetes, Obesity …, 2023 - Wiley Online Library
Obesity is a chronic, progressive and relapsing disease with a rising global prevalence
associated with increased morbidity and mortality and reduced quality of life. Treatment of …

New insights into the structure and function of class B1 GPCRs

BP Cary, X Zhang, J Cao, RM Johnson… - Endocrine …, 2023 - academic.oup.com
G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …

Obesity and diabetes

C Boutari, A DeMarsilis, CS Mantzoros - Diabetes Research and Clinical …, 2023 - Elsevier
Obesity, which has currently reached pandemic dimensions, is usually accompanied by
diabetes mellitus type 2 (T2DM). These two conditions share common pathophysiological …

[HTML][HTML] Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity

AM Angelidi, A Kokkinos, D Sanoudou, MA Connelly… - Metabolism, 2023 - Elsevier
Background Glucagon-like peptide-1 receptor agonists (GLP-1RA) and bariatric surgery
have proven to be effective treatments for obesity and cardiometabolic conditions. We aimed …

Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical …

M Kokkorakis, A Katsarou, N Katsiki, CS Mantzoros - Metabolism, 2023 - Elsevier
The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

[HTML][HTML] How far beyond diabetes can the benefits of glucagon-like peptide-1 receptor agonists go? A review of the evidence on their effects on hepatocellular …

K Arvanitakis, T Koufakis, K Kotsa, G Germanidis - Cancers, 2022 - mdpi.com
Simple Summary Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were drugs
originally intended for the management of diabetes, while their role on the treatment of …

Obesity, metabolic phenotypes and COVID-19

D Sanoudou, MA Hill, MJ Belanger, K Arao… - Metabolism, 2022 - Elsevier
The pandemic resulting from the acute respiratory SARS-CoV-2 infection and the associated
COVID-19 syndrome is reaching its third year and has impacted all regions of the globe. At …