Bioactive peptides have potential as drug leads, but turning them into drugs is a challenge
because of their typically poor metabolic stability. Molecular grafting is one approach to …

Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …

Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled
receptors, has directly enabled the discovery of most drugs developed to modulate receptor …

Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors
(GABAARs) that are enriched at functionally diverse synapses via mechanisms that remain …

Super‐resolution microscopy requires small fluorescent labels. We report the application of
genetic code expansion in combination with bioorthogonal click chemistry to label the NR1 …

To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise
apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein …

Ubiquitous expression of GABA type A receptors (GABAAR) in the central nervous system
establishes their central role in coordinating most aspects of neural function and …

Targeted therapy for neuropsychiatric disorders requires selective modulation of
dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have …

Gephyrin (GPHN) regulates the clustering of postsynaptic components at inhibitory
synapses and is involved in pathophysiology of neuropsychiatric disorders. Here, we …

Glycine and γ-aminobutyric acid (GABA) are the major determinants of inhibition in the
central nervous system (CNS). These neurotransmitters target glycine and GABAA …