Multiscale lipid membrane dynamics as revealed by neutron spectroscopy

VK Sharma, E Mamontov - Progress in Lipid Research, 2022 - Elsevier
The plasma membrane is one of the principal structural components of the cell and,
therefore, one of the key components of the cellular life. Because the membrane's dynamics …

[HTML][HTML] Dioctadecyldimethylammonium bromide, a surfactant model for the cell membrane: Importance of microscopic dynamics

VK Sharma, H Srinivasan, V García Sakai… - Structural Dynamics, 2020 - pubs.aip.org
Cationic lipid membranes have recently attracted huge attention both from a fundamental
point of view and due to their practical applications in drug delivery and gene therapy. The …

Ubiquicidin-derived peptides selectively interact with the anionic phospholipid membrane

J Bhatt Mitra, VK Sharma, A Mukherjee… - Langmuir, 2019 - ACS Publications
Ubiquicidin (UBI)/ribosomal protein S30 (RS30) is an intracellular protein with antimicrobial
activities against various pathogens. UBI (29–41) and UBI (31–38) are two crucial peptides …

Membrane softening by nonsteroidal anti-inflammatory drugs investigated by neutron spin echo

VK Sharma, M Nagao, DK Rai… - Physical Chemistry …, 2019 - pubs.rsc.org
In spite of their well-known side effects, the nonsteroidal anti-inflammatory drugs (NSAIDs)
are one of the most commonly prescribed medications for their antipyretic and anti …

Dynamic landscape in self-assembled surfactant aggregates

VK Sharma, S Mitra, R Mukhopadhyay - Langmuir, 2019 - ACS Publications
A process in which a disordered system of pre-existing molecules generates an organized
structure through specific, local interactions among the molecules themselves is termed …

Aspirin-Induced Ordering and Faster Dynamics of a Cationic Bilayer for Drug Encapsulation

S Sahu, H Srinivasan, SE Jadhav, VK Sharma… - Langmuir, 2023 - ACS Publications
The lipid dynamics and phase play decisive roles in drug encapsulation and delivery to the
intracellular target. Thus, understanding the dynamic and structural alterations of …

Modulation of Phase Behavior and Microscopic Dynamics in Cationic Vesicles by 1-Decyl-3-methylimidazolium Bromide

J Gupta, VK Sharma, H Srinivasan, H Bhatt, VG Sakai… - Langmuir, 2023 - ACS Publications
Synthetic cationic lipids have garnered significant attention as promising candidates for
gene/DNA transfection in therapeutic applications. The phase behavior of the vesicles …

Microscopic diffusion in cationic vesicles across different phases

J Gupta, VK Sharma, H Srinivasan, H Bhatt… - Physical Review …, 2022 - APS
Understanding the phase behavior and microscopic diffusion mechanism of cationic
vesicles is crucial for controlled-release kinetics in gene/DNA transfection. Here, we report …

Lipid lateral diffusion: mechanisms and modulators

VK Sharma, H Srinivasan, J Gupta, S Mitra - Soft Matter, 2024 - pubs.rsc.org
The lateral diffusion of lipids within membrane is of paramount importance, serving as a
central mechanism in numerous physiological processes including cell signaling …

Caffeine modulates the dynamics of DODAB membranes: Role of the physical state of the bilayer

VK Sharma, H Srinivasan, V García Sakai… - Journal of Applied …, 2020 - pubs.aip.org
Caffeine (1, 3, 7-trimethylxanthine), an ingredient of coffee, is used worldwide as a
psychostimulant, antioxidant, and adjuvant analgesic. To gain insights into the action …