ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV

L Lubbe, GE Cozier, D Oosthuizen, KR Acharya… - Clinical …, 2020 - portlandpress.com
Angiotensin converting enzyme (ACE) is well-known for its role in blood pressure regulation
via the renin–angiotensin aldosterone system (RAAS) but also functions in fertility, immunity …

Spider venom: components, modes of action, and novel strategies in transcriptomic and proteomic analyses

N Langenegger, W Nentwig, L Kuhn-Nentwig - Toxins, 2019 - mdpi.com
This review gives an overview on the development of research on spider venoms with a
focus on structure and function of venom components and techniques of analysis. Major …

The deep-rooted origin of disulfide-rich spider venom toxins

NY Shaikh, K Sunagar - Elife, 2023 - elifesciences.org
Spider venoms are a complex concoction of enzymes, polyamines, inorganic salts, and
disulfide-rich peptides (DRPs). Although DRPs are widely distributed and abundant, their …

Biologically active peptides from venoms: applications in antibiotic resistance, cancer, and beyond

L Ageitos, MDT Torres… - International Journal of …, 2022 - mdpi.com
Peptides are potential therapeutic alternatives against global diseases, such as
antimicrobial-resistant infections and cancer. Venoms are a rich source of bioactive peptides …

Deadly proteomes: a practical guide to proteotranscriptomics of animal venoms

AA Walker, SD Robinson, BF Hamilton… - …, 2020 - Wiley Online Library
Animal venoms are renowned for their toxicity, biochemical complexity, and as a source of
compounds with potential applications in medicine, agriculture, and industry. Polypeptides …

Enlightening the toxinological dark matter of spider venom enzymes

J Dresler, V Herzig, A Vilcinskas, T Lüddecke - npj Biodiversity, 2024 - nature.com
Spiders produce highly adapted venoms featuring a complex mixture of biomolecules used
mainly for hunting and defense. The most prominent components are peptidic neurotoxins, a …

Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications

R Guo, G Guo, A Wang, G Xu, R Lai, H Jin - Molecules, 2023 - mdpi.com
Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity,
with 47,000 described species and an estimated 150,000 species in existence. Evolving …

The Dual Prey-Inactivation Strategy of Spiders—In-Depth Venomic Analysis of Cupiennius salei

L Kuhn-Nentwig, N Langenegger, M Heller, D Koua… - Toxins, 2019 - mdpi.com
Most knowledge of spider venom concerns neurotoxins acting on ion channels, whereas
proteins and their significance for the envenomation process are neglected. The here …

Venomics of the milos viper (Macrovipera schweizeri) unveils patterns of venom composition and exochemistry across blunt-nosed viper venoms

L Schulte, M Damm, I Avella, L Uhrig… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Snakebite is a neglected tropical disease and a globally important driver of
death and morbidity. Vipers of the genus Macrovipera (Viperidae: Viperinae) are among the …

Holistic profiling of the venom from the Brazilian wandering spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics

FC Cardoso, AA Walker, GF King… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Spider venoms are a unique source of bioactive peptides, many of which
display remarkable biological stability and neuroactivity. Phoneutria nigriventer, often …