Follicle-stimulating hormone (FSH) action on spermatogenesis: a focus on physiological and therapeutic roles

D Santi, P Crépieux, E Reiter, G Spaggiari… - Journal of Clinical …, 2020 - mdpi.com
Background: Human reproduction is regulated by the combined action of the follicle-
stimulating hormone (FSH) and the luteinizing hormone (LH) on the gonads. Although FSH …

Male infertility and gonadotropin treatment: What can we learn from real-world data?

SC Esteves, APP Achermann, M Simoni, D Santi… - Best Practice & …, 2023 - Elsevier
Gonadotropin therapy to treat specific male infertility disorders associated with
hypogonadotropic hypogonadism is evidence-based and effective in restoring …

Follicle-stimulating hormone-mediated decline in miR-92a-3p expression in pubertal mice Sertoli cells is crucial for germ cell differentiation and fertility

A Gupta, A Vats, A Ghosal, K Mandal, R Sarkar… - Cellular and Molecular …, 2022 - Springer
Sertoli cells (Sc) are the sole target of follicle-stimulating hormone (FSH) in the testis and
attain functional maturation post-birth to significantly augment germ cell (Gc) division and …

Iron and a man's reproductive health: the good, the bad, and the ugly

JS Gabrielsen, DJ Lamb, LI Lipshultz - Current urology reports, 2018 - Springer
Abstract Purpose of Review To discuss the physiologic and pathologic effects of iron on
men's reproductive health. Recent Findings Iron overload diseases are associated with …

Follicle-stimulating hormone receptor: advances and remaining challenges

F De Pascali, A Tréfier, F Landomiel, V Bozon… - International review of …, 2018 - Elsevier
Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for
reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells …

Declining levels of miR-382-3p at puberty trigger the onset of spermatogenesis

A Gupta, K Mandal, P Singh, R Sarkar… - … Therapy-Nucleic Acids, 2021 - cell.com
A major change in the transcriptome of testicular Sertoli cells (Scs) at the onset of puberty
enables them to induce robust spermatogenesis. Through comprehensive literature mining …

Hormone induced differential transcriptome analysis of Sertoli cells during postnatal maturation of rat testes

M Gautam, I Bhattacharya, U Rai, SS Majumdar - PloS one, 2018 - journals.plos.org
Sertoli cells (Sc) are unique somatic cells of testis that are the target of both FSH and
testosterone (T) and regulate spermatogenesis. Although Sc of neonatal rat testes are …

Pubertal down-regulation of Tetraspanin 8 in testicular Sertoli cells is crucial for male fertility

BS Pradhan, I Bhattacharya, R Sarkar… - Molecular Human …, 2020 - academic.oup.com
The alarming decline in sperm count has become a global concern in the recent decades.
The division and differentiation of male germ cells (Gc) into sperm are governed by Sertoli …

Claudins: new players in human fertility and reproductive system cancers

MJ Kozieł, K Kowalska, AW Piastowska-Ciesielska - Cancers, 2020 - mdpi.com
Claudins are major integral proteins of tight junctions (TJs), the apical cell–cell adhesions
that enable maintaining polarity of epithelial cells, their differentiation, and cell signaling. A …

Downregulation of Sostdc1 in testicular Sertoli cells is prerequisite for onset of robust spermatogenesis at puberty

BS Pradhan, I Bhattacharya, R Sarkar… - Scientific Reports, 2019 - nature.com
An alarming decline in sperm count of men from several countries has become a major
concern for the world community. Hormones act on testicular Sertoli cells (Sc) to regulate …