Osteoarthritis and toll-like receptors: when innate immunity meets chondrocyte apoptosis

G Barreto, M Manninen, K K. Eklund - Biology, 2020 - mdpi.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Proton pump inhibitor therapy for eosinophilic esophagitis: history, mechanisms, efficacy, and future directions

JP Franciosi, EB Mougey, ES Dellon… - Journal of asthma …, 2022 - Taylor & Francis
Over the past decade, the role of proton pump inhibitor (PPI) medication has evolved from a
diagnostic tool for Eosinophilic Esophagitis (EoE), by excluding patients with PPI responsive …

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing

JJ Lima, CD Thomas, J Barbarino… - Clinical …, 2021 - Wiley Online Library
Proton pump inhibitors (PPIs) are widely used for acid suppression in the treatment and
prevention of many conditions, including gastroesophageal reflux disease, gastric and …

Diagnosis and management of eosinophilic esophagitis in children: An update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition …

J Amil‐Dias, S Oliva, A Papadopoulou… - Journal of Pediatric …, 2024 - Wiley Online Library
Abstract Introduction Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the
esophagus characterized by symptoms of esophageal dysfunction and histologically by …

Treatment of eosinophilic esophagitis: diet or medication?

M Chehade, SS Aceves - The Journal of Allergy and Clinical Immunology …, 2021 - Elsevier
Eosinophilic esophagitis (EoE) is an antigen-triggered chronic disease of increasing
prevalence in children and adults. Untreated or therapy-resistant EoE leads to complications …

Phenotypes and endotypes in eosinophilic esophagitis

MA Ruffner, A Cianferoni - Annals of Allergy, Asthma & Immunology, 2020 - Elsevier
Objective To improve understanding of the heterogeneous presentation of eosinophilic
esophagitis (EoE), and its different potential phenotypes and endotypes. Data Sources We …

IL-13–induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis

S Marella, A Sharma, V Ganesan… - Journal of Allergy and …, 2023 - Elsevier
Background Basal zone hyperplasia (BZH) and dilated intercellular spaces (DISs) are
thought to contribute to the clinical manifestations of eosinophilic esophagitis (EoE); …

Current treatment options and long-term outcomes in patients with eosinophilic esophagitis

AJ Lucendo, J Molina-Infante - Expert review of clinical …, 2022 - Taylor & Francis
Introduction Dietary and pharmacological (proton pump inhibitors, swallowed topical
corticosteroids) therapies are effective for induction of clinical and histological remission of …

Genetic and molecular contributors in eosinophilic esophagitis

H Sato, K Osonoi, CS Sharlin, T Shoda - Current allergy and asthma …, 2023 - Springer
Abstract Purpose of Review Eosinophilic esophagitis (EoE) is an allergic inflammatory
esophageal disorder with a complex underlying genetic and molecular etiology. The interest …

Proton pump inhibitor therapy in pediatric eosinophilic esophagitis: predictive factors and long-term step-down efficacy

C Gutiérrez-Junquera… - Journal of pediatric …, 2023 - journals.lww.com
Objectives: To assess the short-and long-term efficacy of proton pump inhibitor (PPI) therapy
for pediatric eosinophilic esophagitis (EoE) in real-world practice with a step-down strategy …