[HTML][HTML] The emerging role of oncolytic virus therapy against cancer

L Russell, KW Peng - Chinese clinical oncology, 2018 - ncbi.nlm.nih.gov
This review discusses current clinical advancements in oncolytic viral therapy, with a focus
on the viral platforms approved for clinical use and highlights the benefits each platform …

Oncolytic virus combination therapy: killing one bird with two stones

NT Martin, JC Bell - Molecular Therapy, 2018 - cell.com
Over the last 60 years an eclectic collection of microbes has been tested in a variety of pre-
clinical models as anti-cancer agents. At the forefront of this research are a number of virus …

Designing and building oncolytic viruses

J Maroun, M Muñoz-Alía, A Ammayappan… - Future …, 2017 - Taylor & Francis
Oncolytic viruses (OVs) are engineered and/or evolved to propagate selectively in
cancerous tissues. They have a dual mechanism of action; direct killing of infected cancer …

Recent advances in vesicular stomatitis virus-based oncolytic virotherapy: a 5-year update

SA Felt, VZ Grdzelishvili - Journal of General Virology, 2017 - microbiologyresearch.org
Oncolytic virus (OV) therapy is an anti-cancer approach that uses viruses that preferentially
infect, replicate in and kill cancer cells. Vesicular stomatitis virus (VSV, a rhabdovirus) is an …

PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance

L Russell, J Swanner, AC Jaime-Ramirez… - Nature …, 2018 - nature.com
Engineered oncolytic viruses are used clinically to destroy cancer cells and have the ability
to boost anticancer immunity. Phosphatase and tensin homolog deleted on chromosome 10 …

Oncolytic potency and reduced virus tumor-specificity in oncolytic virotherapy. A mathematical modelling approach

KJ Mahasa, A Eladdadi, L De Pillis, R Ouifki - Plos one, 2017 - journals.plos.org
In the present paper, we address by means of mathematical modeling the following main
question: How can oncolytic virus infection of some normal cells in the vicinity of tumor cells …

Fusogenic viruses in oncolytic immunotherapy

T Krabbe, J Altomonte - Cancers, 2018 - mdpi.com
Oncolytic viruses are under intense development and have earned their place among the
novel class of cancer immunotherapeutics that are changing the face of cancer therapy …

Syncytia formation in oncolytic virotherapy

C Burton, E Bartee - Molecular Therapy-Oncolytics, 2019 - cell.com
Oncolytic virotherapy uses replication-competent virus as a means of treating cancer.
Whereas this field has shown great promise as a viable treatment method, the limited spread …

Advancing aptamers as molecular probes for cancer theranostic applications—the role of molecular dynamics simulation

J Jeevanandam, KX Tan, MK Danquah… - Biotechnology …, 2020 - Wiley Online Library
Theranostics cover emerging technologies for cell biomarking for disease diagnosis and
targeted introduction of drug ingredients to specific malignant sites. Theranostics …

Potential and clinical translation of oncolytic measles viruses

S Robinson, E Galanis - Expert opinion on biological therapy, 2017 - Taylor & Francis
Introduction: Oncolytic viruses represent a novel treatment modality that is unencumbered by
the standard resistance mechanisms limiting the therapeutic efficacy of conventional …