Chronic obstructive pulmonary disease (COPD) is a major global health problem that is
poorly treated by current therapies as it has proved difficult to treat the underlying …

Chronic obstructive pulmonary disease (COPD) involves chronic inflammation of the lung,
particularly in peripheral airways and parenchyma, which increases during acute …

Reduced responsiveness to the anti-inflammatory effects of corticosteroids is a major barrier
to effective management of asthma in smokers and patients with severe asthma and in the …

Asthma and chronic obstructive pulmonary disease (COPD) are both obstructive airway
diseases that involve chronic inflammation of the respiratory tract, but the type of …

Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several
common inflammatory diseases—including chronic obstructive pulmonary disease and …

Compared with the effects of chronic smoke exposure on lung function and airway
inflammation, there are few data on the acute effects of smoking. A review of the literature …

The small airways are defined as those less than 2 mm in diameter. They are a major site of
pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) …

There has recently been an explosion of interest in the analysis of breath constituents as a
way of monitoring inflammation and oxidative stress in the lungs. Here we review the use of …

The upregulation of nitric oxide (NO) by inflammatory cytokines and mediators in central and
peripheral airway sites can be monitored easily in exhaled air. It is now possible to estimate …

Background Patients with COPD may share some clinical characteristics with asthma
sufferers. This phenotypic overlap between COPD and asthma is not yet well characterised …