Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications

L Saba, T Saam, HR Jäger, C Yuan… - The Lancet …, 2019 - thelancet.com
Stroke represents a massive public health problem. Carotid atherosclerosis plays a
fundamental part in the occurence of ischaemic stroke. European and US guidelines for …

Roadmap consensus on carotid artery plaque imaging and impact on therapy strategies and guidelines: an international, multispecialty, expert review and position …

L Saba, W Brinjikji, JD Spence… - American Journal …, 2021 - Am Soc Neuroradiology
Current guidelines for primary and secondary prevention of stroke in patients with carotid
atherosclerosis are based on the quantification of the degree of stenosis and symptom …

MR imaging of carotid artery atherosclerosis: updated evidence on high-risk plaque features and emerging trends

JC Benson, L Saba, G Bathla, W Brinjikji… - American Journal of …, 2023 - ajnr.org
MR imaging is well-established as the criterion standard for carotid artery atherosclerosis
imaging. The capability of MR imaging to differentiate numerous plaque components has …

Benefits and drawbacks of statins and non-statin lipid lowering agents in carotid artery disease

KI Paraskevas, P Gloviczki, PL Antignani… - Progress in …, 2022 - Elsevier
International guidelines strongly recommend statins alone or in combination with other lipid-
lowering agents to lower low-density lipoprotein cholesterol (LDL-C) levels for patients with …

Carotid plaque echogenicity predicts cerebrovascular symptoms: a systematic review and meta‐analysis

F Jashari, P Ibrahimi, G Bajraktari… - European journal of …, 2016 - Wiley Online Library
Background and purpose Many reports have shown an association between hypoechoic
(echolucent) carotid atherosclerotic plaques and unstable features. In this meta‐analysis our …

[HTML][HTML] Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis

F Khan, I Goncalves, AC Shore, A Natali… - Cell Reports …, 2022 - cell.com
The factors that influence the atherosclerotic disease process in high-risk individuals remain
poorly understood. Here, we used a combination of vascular imaging, risk factor …

A new approach of statin therapy in carotid atherosclerosis: Targeting indices of plaque vulnerability on the top of lipid-lowering. A narrative review

NPE Kadoglou, E Khattab, N Velidakis… - Polish Heart …, 2022 - journals.viamedica.pl
Novel imaging techniques and biomarkers have emerged as surrogate markers of carotid
plaque vulnerability. In parallel, statin administration in patients with established carotid …

Advances in noninvasive carotid wall imaging with ultrasound: a narrative review

M Alexandratou, A Papachristodoulou, X Li… - Journal of Clinical …, 2022 - mdpi.com
Carotid atherosclerosis is a major cause for stroke, with significant associated disease
burden morbidity and mortality in Western societies. Diagnosis, grading and follow-up of …

Triglyceride-glucose index is related to carotid plaque and its stability in nondiabetic adults: a cross-sectional study

A Wang, Y Li, L Zhou, K Liu, S Li, B Song, Y Gao… - Frontiers in …, 2022 - frontiersin.org
Background Carotid plaque plays an important role in the development of stroke. The
triglyceride-glucose (TyG) index is a reliable alternative marker of insulin resistance …

Previous statin use and high-resolution magnetic resonance imaging characteristics of intracranial atherosclerotic plaque: the intensive statin treatment in acute …

JW Chung, J Hwang, MJ Lee, J Cha, OY Bang - Stroke, 2016 - Am Heart Assoc
Background and Purpose—Although statin use has been linked to the stabilization of
systemic atherosclerosis, its effect on symptomatic intracranial atherosclerotic plaques has …