Roles of Porphyromonas gingivalis and its virulence factors in periodontitis

W Xu, W Zhou, H Wang, S Liang - Advances in protein chemistry and …, 2020 - Elsevier
Periodontitis is an infection-driven inflammatory disease, which is characterized by gingival
inflammation and bone loss. Periodontitis is associated with various systemic diseases …

Gum Bug, Leave My Heart Alone!”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

M Kebschull, RT Demmer… - Journal of dental …, 2010 - journals.sagepub.com
Evidence from epidemiologic studies suggests that periodontal infections are independently
associated with subclinical and clinical atherosclerotic vascular disease. Although the …

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

SS Dominy, C Lynch, F Ermini, M Benedyk… - Science …, 2019 - science.org
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in
the brain of Alzheimer's disease patients. Toxic proteases from the bacterium called …

The periodontal pocket: pathogenesis, histopathology and consequences

DD Bosshardt - Periodontology 2000, 2018 - Wiley Online Library
The conversion of junctional epithelium to pocket epithelium is regarded as a hallmark in the
development of periodontitis. Knowledge of factors contributing to the initiation and …

[HTML][HTML] Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation …

Y Guo, KA Nguyen, J Potempa - Periodontology 2000, 2010 - ncbi.nlm.nih.gov
Arguably periodontitis is the most prevalent bacteria-driven chronic inflammatory disease of
the humankind. The incidence of periodontal disease has been reported to range from 30 …

Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration

I Raimondi, L Izzo, M Tunesi, M Comar… - … in bioengineering and …, 2020 - frontiersin.org
We are accumulating evidence that intestinal microflora, collectively named gut microbiota,
can alter brain pathophysiology, but researchers have just begun to discover the …

Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity

Y Fardini, X Wang, S Témoin… - Molecular …, 2011 - Wiley Online Library
Fusobacterium nucleatum is a Gram‐negative oral anaerobe, capable of systemic
dissemination causing infections and abscesses, often in mixed‐species, at different body …

Experimental evidence for the age dependence of tau protein spread in the brain

S Wegmann, RE Bennett, L Delorme, AB Robbins… - Science …, 2019 - science.org
The incidence of Alzheimer's disease (AD), which is characterized by progressive cognitive
decline that correlates with the spread of tau protein aggregation in the cortical mantle, is …

Intracellular Porphyromonas gingivalis Promotes the Proliferation of Colorectal Cancer Cells via the MAPK/ERK Signaling Pathway

W Mu, Y Jia, X Chen, H Li, Z Wang… - Frontiers in Cellular and …, 2020 - frontiersin.org
Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen in periodontitis. However,
several clinical studies have revealed an enrichment of P. gingivalis in the stool samples …

Links between atherosclerotic and periodontal disease

DA Chistiakov, AN Orekhov, YV Bobryshev - Experimental and molecular …, 2016 - Elsevier
Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the
modern community. Both pathologies are chronic inflammatory disorders, which are …