The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …

Polysaccharide-encapsulated organisms are the leading cause of bacterial meningitis and
pneumonia in children. The use of protein–polysaccharide conjugate vaccines in developed …

The immunogenicity of polysaccharides as human vaccines was enhanced by coupling to
protein carriers. Conjugation transformed the T cell-independent polysaccharide vaccines of …

Glycoconjugate vaccines are among the most effective interventions for preventing several
serious infectious diseases. Covalent linkage of the bacterial capsular polysaccharide to a …

Abstract On October 27, 2010, the Advisory Committee on Immunization Practices (ACIP)
approved updated recommendations for the use of quadrivalent (serogroups A, C, Y, and W …

Complement is an essential component of the immune system and human pathogenic
organisms have developed various mechanisms for evading complement mediated serum …

In this review we discuss the effects of microbial exposure on the B cell repertoire. Neonatal
exposure to conserved bacterial carbohydrates and phospholipids permanently reprograms …

Introduction: Globally, the three main pathogens causing serious infections are
Haemophilus influenzae type b, Streptococcus pneumoniae and Neisseria meningitidis …

Objective To determine the persistence of bactericidal antibody titres following immunisation
with serogroup C meningococcal glycoconjugate vaccine at age 6-15 years in order to …

Almost all current vaccines work by the induction of antibodies in serum or on the mucosa to
block adherence of pathogens to epithelial cells or interfere with microbial invasion of the …