Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Potassium channels are a diverse group of pore-forming transmembrane proteins that
selectively facilitate potassium flow through an electrochemical gradient. They participate in …

A distinct gene family of widely distributed and well-modulated two-pore-domain
background potassium (K 2P) channels establish resting membrane potential and cell …

TASK1 (KCNK3) and TASK3 (KCNK9) are two‐pore domain potassium channels highly
expressed in adrenal glands. TASK1/TASK3 heterodimers are believed to contribute to the …

Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

Over the last decade, we have seen an enormous increase in the number of experimental
studies on two-pore-domain potassium channels (K 2P-channels). The collection of reviews …

Central respiratory chemoreception is the mechanism by which the CNS maintains
physiologically appropriate pH and PCO2 via control of breathing. A prominent hypothesis …

Epithelial cells of the gastrointestinal tract are an important barrier between the “milieu
interne” and the luminal content of the gut. They perform transport of nutrients, salts, and …

Two-pore domain (K 2P) channels emerged about a decade ago and since then have been
an expanding area of interest. This is because their biophysical and pharmacological …

The ability of neurons, such as cerebellar granule neurons (CGNs), to fire action potentials
(APs) at high frequencies during sustained depolarization is usually explained in relation to …