Defining trained immunity and its role in health and disease

MG Netea, J Domínguez-Andrés, LB Barreiro… - Nature Reviews …, 2020 - nature.com
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Trained immunity: a program of innate immune memory in health and disease

MG Netea, LAB Joosten, E Latz, KHG Mills, G Natoli… - Science, 2016 - science.org
BACKGROUND Host immune responses are classically divided into innate immune
responses, which react rapidly and nonspecifically upon encountering a pathogen, and …

Trained immunity: a memory for innate host defense

MG Netea, J Quintin, JWM Van Der Meer - Cell host & microbe, 2011 - cell.com
Immune responses in vertebrates are classically divided into innate and adaptive, with only
the latter being able to build up immunological memory. However, although lacking adaptive …

A small jab–a big effect: nonspecific immunomodulation by vaccines

CS Benn, MG Netea, LK Selin, P Aaby - Trends in immunology, 2013 - cell.com
Recent epidemiological studies have shown that, in addition to disease-specific effects,
vaccines against infectious diseases have nonspecific effects on the ability of the immune …

Harnessing the beneficial heterologous effects of vaccination

HS Goodridge, SS Ahmed, N Curtis… - Nature Reviews …, 2016 - nature.com
Clinical evidence strongly suggests that certain live vaccines, in particular bacille Calmette–
Guérin (BCG) and measles vaccines, can reduce all-cause mortality, most probably through …

Could the induction of trained immunity by β-glucan serve as a defense against COVID-19?

A Geller, J Yan - Frontiers in immunology, 2020 - frontiersin.org
As the SARS-CoV-2 virus wreaks havoc on the populations, health care infrastructures and
economies of nations around the world, finding ways to protect health care workers and …

Innate immune memory: towards a better understanding of host defense mechanisms

J Quintin, SC Cheng, JWM van Der Meer… - Current opinion in …, 2014 - Elsevier
Highlights•Organisms lacking an adaptive immune system can mount resistance to
secondary infections.•NK cells and monocytes have adaptive (memory) characteristics.• …

Trained immunity: a smart way to enhance innate immune defence

JWM van der Meer, LAB Joosten, N Riksen… - Molecular …, 2015 - Elsevier
The innate arm of the immune system is generally viewed as primitive and non-specific and–
in contrast to the adaptive immune arm–not to possess memory. However in plants and …

The complexity of fungal β-glucan in health and disease: effects on the mononuclear phagocyte system

G Camilli, G Tabouret, J Quintin - Frontiers in immunology, 2018 - frontiersin.org
β-glucan, the most abundant fungal cell wall polysaccharide, has gained much attention
from the scientific community in the last few decades for its fascinating but not yet fully …