Molecular biology of coronaviruses: current knowledge

IM Artika, AK Dewantari, A Wiyatno - Heliyon, 2020 - cell.com
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) late
December 2019 in Wuhan, China, marked the third introduction of a highly pathogenic …

SARS-CoV-2 evolutionary adaptation toward host entry and recognition of receptor O-Acetyl sialylation in virus–host interaction

CH Kim - International journal of molecular sciences, 2020 - mdpi.com
The recently emerged SARS-CoV-2 is the cause of the global health crisis of the coronavirus
disease 2019 (COVID-19) pandemic. No evidence is yet available for CoV infection into …

SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2

TM Clausen, DR Sandoval, CB Spliid, J Pihl… - Cell, 2020 - cell.com
We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and
angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD) …

[HTML][HTML] Acute limb ischemia in patients with COVID-19 pneumonia

R Bellosta, L Luzzani, G Natalini, MA Pegorer… - Journal of vascular …, 2020 - Elsevier
Objective The aim of our study was to determine the incidence, characteristics, and clinical
outcomes of patients with the novel coronavirus (COVID-19) infection who had presented …

The biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria

DB Kell, EL Heyden, E Pretorius - Frontiers in immunology, 2020 - frontiersin.org
Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred
via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has …

Can graphene take part in the fight against COVID-19?

V Palmieri, M Papi - Nano Today, 2020 - Elsevier
The pneumonia outbreak of coronavirus disease 2019 (COVID-19) represents a global
issue. The bidimensional material graphene has captured much attention due to promising …

The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor

Y Hu, X Meng, F Zhang, Y Xiang… - Emerging microbes & …, 2021 - Taylor & Francis
ABSTRACT Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that lacks
effective therapeutic interventions. SARS-CoV-2 infects ACE2-expressing cells and gains …

Sars‐CoV‐2 envelope and membrane proteins: Structural differences linked to virus characteristics?

M Bianchi, D Benvenuto, M Giovanetti… - BioMed Research …, 2020 - Wiley Online Library
The Coronavirus Disease 2019 (COVID‐19) is a new viral infection caused by the severe
acute respiratory coronavirus 2 (SARS‐CoV‐2). Genomic analyses have revealed that …

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

Q Zhang, CZ Chen, M Swaroop, M Xu, L Wang, J Lee… - Cell discovery, 2020 - nature.com
The cell entry of SARS-CoV-2 has emerged as an attractive drug repurposing target for
COVID-19. Here we combine genetics and chemical perturbation to demonstrate that ACE2 …

Structure and dynamics of membrane protein in SARS-CoV-2

R Mahtarin, S Islam, MJ Islam, MO Ullah… - Journal of …, 2022 - Taylor & Francis
Abstract SARS-CoV-2 membrane (M) protein performs a variety of critical functions in virus
infection cycle. However, the expression and purification of membrane protein structure is …