Nanotechnology-empowered combination therapy for rheumatoid arthritis: Principles, strategies, and challenges

S Ren, Y Xu, X Dong, Q Mu, X Chen, Y Yu… - Journal of …, 2024 - Springer
Rheumatoid arthritis (RA) is an autoimmune disease with multifactorial etiology and intricate
pathogenesis. In RA, repeated monotherapy is frequently associated with inadequate …

Sphingosine 1-phosphate signaling during infection and immunity

S Mohammed, A Bindu, A Viswanathan… - Progress in Lipid …, 2023 - Elsevier
Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

Bridging the gap in rheumatoid arthritis treatment with hyaluronic acid-based drug delivery approaches

S Priya, J Daryani, VM Desai, G Singhvi - International Journal of Biological …, 2024 - Elsevier
Rheumatoid Arthritis (RA) is a chronic, inflammatory, auto-immune disease that is majorly
associated with the degradation of the synovial linings of the joints. It is a progressive …

Recent developments in the synovial fibroblast pathobiology field in rheumatoid arthritis

E Neumann, C Heck… - Current Opinion in …, 2024 - journals.lww.com
Highly interesting findings revealing mechanisms of RASF activation and altered functions
have been published, RASF subsets further characterized, and interactions with cell types …

[HTML][HTML] The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis

A Gardette, V Marzaioli, S Bedouhene, G Hayem… - Free Radical Biology …, 2025 - Elsevier
Neutrophils are essential for host defense against infections, but they also play a key role in
acute and chronic inflammation. The protein tyrosine phosphatase non-receptor type 22 …

Emerging Phytochemical Formulations for Management of Rheumatoid Arthritis: A Review

P Pimple, J Shah, P Singh - Current Drug Delivery, 2025 - benthamdirect.com
Rheumatoid arthritis (RA) is a T-cell-mediated chronic inflammatory disorder affecting 0.5-
1% of the global population. The disease with unknown etiology causes slow destruction of …

Eupalinolide B alleviates rheumatoid arthritis through the promotion of apoptosis and autophagy via regulating the AMPK/mTOR/ULK-1 signaling axis

S Gu, X Liu, Z Xu, L Li, X Wu, F Li, Y Huang… - International …, 2025 - Elsevier
The excessive proliferation of fibroblast-like synoviocytes (FLS) leads to synovial
hyperplasia, a key pathological hallmark of rheumatoid arthritis (RA). Eupalinolide B (EB), a …

[HTML][HTML] The combination of hydrogels and rutin-loaded black phosphorus nanosheets treats rheumatoid arthritis

J Hou, S Yin, R Jiao, W Chen, W Wang, H Zhang… - Materials Today Bio, 2024 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by
inflammation, joint pain, and cartilage degradation. The fluctuating nature of RA often …

A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m

M Ali, V Benfante, D Di Raimondo, R Laudicella… - Life, 2024 - mdpi.com
Rheumatoid arthritis (RA) is a systemic autoimmune disorder caused by inflammation of
cartilaginous diarthrodial joints that destroys joints and cartilage, resulting in synovitis and …

L-selectin Promotes Migration, Invasion and Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via NF-kB Signaling Pathway

W Wu, Z Cheng, Y Nan, G Pan, Y Wang - Inflammation, 2025 - Springer
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by
chronic inflammation of the synovium and progressive joint damage. Fibroblast-like …