Acute kidney injury (AKI) is a clinical syndrome that complicates the course and worsens the
outcome in a significant number of hospitalised patients. Recent advances in clinical and …

Dysregulated host immune responses to infection often occur, leading to sepsis, multiple
organ failure, and death. Some patients rapidly recover from sepsis, but many develop …

Objective: To determine the incremental hospital cost and mortality associated with the
development of postoperative acute kidney injury (AKI) and with other associated …

Sepsis and trauma were the primary inciting events. With tremendous the advances in care
over the ensuing four decades, the epidemiology of MOF evolved from a fulminant …

Background Organ crosstalk can be defined as the complex and mutual biological
communication between distant organs mediated by signaling factors. Normally, crosstalk …

Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated
and humoral pathways affecting distant organs, contributing to the high therapeutic costs …

In addition to being a leading cause of morbidity and mortality worldwide, sepsis is also the
most common cause of acute kidney injury (AKI). When sepsis leads to the development of …

BACKGROUND Acute kidney injury (AKI) is a common and often catastrophic complication
in hospitalized patients; however, the impact of AKI in surgical sepsis remains unknown. We …

Background: Multiple organ dysfunction (MOD) has plagued intensive care units (ICUs) for
more than four decades, and its epidemiology has evolved because more patients are …

Improved management of severe sepsis has been one of the major health care
accomplishments of the last two decades. Due to enhanced recognition and improved …