Targeting vascular (endothelial) dysfunction

A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

The causal relationship between endothelin-1 and hypertension: focusing on endothelial dysfunction, arterial stiffness, vascular remodeling, and blood pressure …

K Kostov - Life, 2021 - mdpi.com
Hypertension (HTN) is one of the most prevalent diseases worldwide and is among the most
important risk factors for cardiovascular and cerebrovascular complications. It is currently …

Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the …

M Kuntic, M Oelze, S Steven… - European heart …, 2020 - academic.oup.com
Aims Electronic (e)-cigarettes have been marketed as a 'healthy'alternative to traditional
combustible cigarettes and as an effective method of smoking cessation. There are …

[HTML][HTML] Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies

A Daiber, S Chlopicki - Free Radical Biology and Medicine, 2020 - Elsevier
According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

Oxidative stress and endothelial dysfunction in hypertension

E Schulz, T Gori, T Münzel - Hypertension Research, 2011 - nature.com
Systemic arterial hypertension is a highly prevalent cardiovascular risk factor that causes
significant morbidity and mortality, and is becoming an increasingly common health problem …

Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function

A Daiber, F Di Lisa, M Oelze… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are associated with and/or caused by oxidative stress. This
concept has been proven by using the approach of genetic deletion of reactive species …

Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice

T Münzel, A Daiber, S Steven, LP Tran… - European heart …, 2017 - academic.oup.com
Aims Epidemiological studies indicate that traffic noise increases the incidence of coronary
artery disease, hypertension and stroke. The underlying mechanisms remain largely …

[HTML][HTML] Health position paper and redox perspectives-Disease burden by transportation noise

M Sørensen, G Pershagen, JD Thacher, T Lanki… - Redox Biology, 2023 - Elsevier
Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization
concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart …

Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction

T Münzel, C Sinning, F Post, A Warnholtz… - Annals of …, 2008 - Taylor & Francis
Endothelial dysfunction (ED) in the setting of cardiovascular risk factors such as
hypercholesterolemia, hypertension, diabetes mellitus, chronic smoking as well as in …

Endothelial function and coronary artery disease

S Kinlay, P Libby, P Ganz - Current opinion in lipidology, 2001 - journals.lww.com
The endothelium produces a number of vasodilator and vasoconstrictor substances that not
only regulate vasomotor tone, but also the recruitment and activity of inflammatory cells and …