The innate and T-cell mediated immune response during acute and chronic gammaherpesvirus infection

V Rex, R Zargari, M Stempel, S Halle… - Frontiers in Cellular …, 2023 - frontiersin.org
Immediately after entry into host cells, viruses are sensed by the innate immune system,
leading to the activation of innate antiviral effector mechanisms including the type I interferon …

Combination of proviral and antiviral roles of B cell-intrinsic STAT1 expression defines parameters of chronic gammaherpesvirus infection

ER Johansen, DL Schmalzriedt, D Avila, PA Sylvester… - Mbio, 2024 - journals.asm.org
Gammaherpesviruses are species-specific, ubiquitous pathogens that establish lifelong
infection in their hosts and are associated with cancers, including B cell lymphomas. Type I …

Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models

CH Hogan, SM Owens, GV Reynoso, Y Liao, TJ Meyer… - Mbio, 2024 - Am Soc Microbiol
Cancers associated with the oncogenic gammaherpesviruses, Epstein-Barr virus and
Kaposi sarcoma herpesvirus, are notable for their constitutive activation of the transcription …

Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells

WP Mboko, BC Mounce, J Emmer, E Darrah… - Journal of …, 2014 - Am Soc Microbiol
Gammaherpesviruses are ubiquitous pathogens that establish a lifelong infection and are
associated with cancer. In spite of the high seroprevalence of infection, the risk factors that …

Interferon regulatory factor 7 attenuates chronic gammaherpesvirus infection

KE Johnson, CA Aurubin, CN Jondle, PT Lange… - Journal of …, 2020 - Am Soc Microbiol
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections and are
associated with a variety of malignancies, including lymphomas. Interferon regulatory factor …

Bringing Balance: Immune Interactions Regulating Murine Gammaherpesvirus 68 Latency

ST Majeed, CN Jondle - Current Clinical Microbiology Reports, 2024 - Springer
Abstract Purpose of Review Gammaherpesviruses constitute the chief virus family that is
capable of exhibiting true latency. Latency allows the viral genome to override host immune …

Host genetic variation has a profound impact on immune responses mediating control of viral load in chronic gammaherpesvirus infection

EA Holt, CM Waytashek, KJ Sessions… - The Journal of …, 2023 - journals.aai.org
Chronic infection with the gammaherpesvirus EBV is a risk factor for several autoimmune
diseases, and poor control of EBV viral load and enhanced anti-EBV responses elevate this …

Liver X receptors suppress activity of cholesterol and fatty acid synthesis pathways to oppose gammaherpesvirus replication

PT Lange, C Schorl, D Sahoo, VL Tarakanova - MBio, 2018 - Am Soc Microbiol
Gammaherpesviruses are oncogenic pathogens that persist in~ 95% of the adult population.
Cellular metabolic pathways have emerged as important regulators of many viral infections …

Interferon regulatory factor 1 and type I interferon cooperate to control acute gammaherpesvirus infection

WP Mboko, MM Rekow, MP Ledwith, PT Lange… - Journal of …, 2017 - Am Soc Microbiol
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection in> 95% of
adults worldwide and are associated with a variety of malignancies. Coevolution of …

[HTML][HTML] B cell-intrinsic STAT3-mediated support of latency and interferon suppression during murine gammaherpesvirus 68 infection revealed through an in vivo …

CH Hogan, SM Owens, GV Reynoso, V Kirillov… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cancers associated with the oncogenic gammaherpesviruses, Epstein-Barr virus and
Kaposi sarcoma herpesvirus, are notable for their constitutive activation of the transcription …