Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …

Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …

Acinetobacter baumannii is an important nosocomial pathogen. Mechanisms that allow A.
baumannii to cause human infection are still poorly understood. Iron is an essential nutrient …

Introduction: One of the possibilities for reducing the emergence and spread of antibiotic
resistance is the use of anti-resistance compounds capable of resensitizing resistant …

We investigated the function of pyoverdine in the biofilm formation, motility, and spoilage
potential of Pseudomonas fluorescens. We targeted and identified two major genes (pvdA …

Siderophores are iron-chelating molecules that solubilize Fe 3+ for microbial utilization and
facilitate colonization or infection of eukaryotes by liberating host iron for bacterial uptake. By …

Many pathogenic bacteria biosynthesize and excrete small molecule metallophores, known
as siderophores, that are used to extract ferric iron from host sources to satisfy nutritional …

We studied the Escherichia coli outer membrane protein Fiu, a presumed transporter of
monomeric ferric catecholates, by introducing Cys residues in its surface loops and …

Globally, the emergence of anti-microbial resistance in pathogens has become a serious
threat to human health and well-being. Infections caused by drug-resistant microorganisms …