Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint
loading–associated to obesity, malalignment, trauma or joint instability–is a critical risk factor …

A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Biomechanical studies are expanding across a variety of fields, from biomedicine to
biomedical engineering. From the molecular to the system level, mechanical stimuli are …

The interplay between the mechanical properties of cells and the forces that they produce
internally or that are externally applied to them play an important role in maintaining the …

Cell mechanical properties, eg elastic and shear modulus, play vital roles in cell activities
and functions, such as cell growth, cell division, cell motion, and cell adhesion …

The pericellular matrix (PCM) is a narrow tissue region surrounding chondrocytes in articular
cartilage, which together with the enclosed cell (s) has been termed the “chondron.” While …

OBJECTIVE: Articular chondrocytes respond to chemical and mechanical signals depending
on their zone of origin with respect to distance from the tissue surface. However, little is …

Recognition of the growing role of human mesenchymal stem cells (hMSC) in tissue
engineering and regenerative medicine requires a thorough understanding of intracellular …

We examined whether the presence of the cell cortex might explain, in part, why previous
studies using atomic force microscopy (AFM) to measure cell modulus (E) gave higher …