Tuberculosis (TB) still represents an important issue for public health in underdeveloped
countries, but the use of antitumor necrosis factor agents (anti‐TNF) for the treatment of …

Rheumatoid arthritis (RA) is known to be related to an elevated risk of infections because of
its pathobiology and the use of immunosuppressive therapies. Reactivation of latent …

Introduction In the present study we evaluated changes in the B cell phenotype in peripheral
blood and bone marrow (BM) of patients with rheumatoid arthritis (RA) following anti-CD20 …

Current treatments for unwanted antibody responses largely rely on immunosuppressive
drugs compromising overall immunity. New approaches to achieve antigen-specific …

Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and destruction. B
cells play important role in modulating immune responses in RA. In the present study we …

OBJECTIVE: Rituximab has been shown to be effective in refractory rheumatoid arthritis
(RA) in randomized controlled trials, allowing approval by health agencies. Our aim was to …

Objectives. Viruses may contribute to RA. This prompted us to monitor viral load and
response to anti-CD20 therapy in RA patients. Methods. Blood and bone marrow from 35 RA …

Objectives To identify how refractory disease (or relevant terminology variations) in RA and
polyarticular JIA (polyJIA) is defined and establish the key components of such definitions …

In order to characterize the reactivity of B cells against nominal antigens, a method based on
the coupling of antigens onto the surface of fluorescent core polystyrene beads was …

Biologics have advanced the therapy of adult and pediatric arthritis. They have been linked
to rare serious adverse outcomes, but the actual risk of these events is controversial in …