The orexins, also known as hypocretins, are two neuropeptides (orexin A and B or
hypocretin 1 and 2) produced by a few thousand neurons located in the lateral …

Kleine–Levin syndrome (KLS) is a rare, relapsing-remitting disease that affects mostly
adolescents. It is characterized by episodes lasting from 1 to several weeks, and comprises …

The mechanisms underlying the individual need for sleep are unclear. Sleep duration is
indeed influenced by multiple factors, such as genetic background, circadian and …

Recurrent episodes of hypersomnia, hypersexuality, compulsive eating, behavioral and
cognitive disturbances, are the basic clinical features of Kleine-Levin syndrome (KLS). Our …

Abstract Study Objectives Kleine–Levin syndrome (KLS) is characterized by relapsing–
remitting episodes of hypersomnia, cognitive impairment, and behavioral disturbances. We …

The links between attention-deficit hyperactivity disorder (ADHD) and sleep disorders
remain unclear. Specific sleep disorders are a frequent comorbid condition associated with …

Kleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence
of 1–2 per million population. Clear diagnostic criteria are now defined, but effective …

Abstract Hypocretin-1 and 2 (or orexin A and B) are neuropeptides exclusively produced by
a group of neurons in the lateral and dorsomedial hypothalamus that project throughout the …

Kleine-Levin syndrome is a rare recurrent hypersomnia associated with symptoms of
behavioral and cognitive impairment. This article reviews common presenting symptoms …

As early as the 1920s, pathological studies of encephalitis lethargica allowed Von Economo
to correctly identify hypothalamic damage as crucial for the profound associated sleep …