Fungi comprise approximately 20% of all eukaryotic species and are connected to virtually
all life forms on Earth. Yet, their diversity remains contentious, their distribution elusive, and …

Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Highlights•Natural products offer a broad chemical catalog for bio-based product
development.•Genome mining tools for identifying BGCs.•Isoprenoid, nonribosomal peptide …

Covering: 2020 Bioinformatic approaches to document and analyse chemical structures,
biosynthetic gene clusters and analytical data play an important role in the study of natural …

This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …

Fungi produce a vast number of secondary metabolites that shape their interactions with
other organisms and the environment. Characterizing the genes underpinning metabolite …

Primary biosynthetic enzymes involved in the synthesis of lichen polyphenolic compounds
depsides and depsidones are non-reducing polyketide synthases (NR-PKSs), and …

Filamentous fungi are one of the most important producers of secondary metabolites. Some
of them can have a toxic effect on the human body, leading to diseases. On the other hand …

Strategies for natural product dereplication are continually evolving, essentially in lock step
with advances in MS and NMR techniques. MADByTE is a new platform designed to identify …