Genomic findings in schizophrenia and their implications
There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
Machine learning in attention-deficit/hyperactivity disorder: new approaches toward understanding the neural mechanisms
Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent and heterogeneous
neurodevelopmental disorder in children and has a high chance of persisting in adulthood …
neurodevelopmental disorder in children and has a high chance of persisting in adulthood …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study
E Friligkou, S Løkhammer, B Cabrera-Mendoza… - Nature Genetics, 2024 - nature.com
We leveraged information from more than 1.2 million participants, including 97,383 cases, to
investigate the genetics of anxiety disorders across five continental groups. Through …
investigate the genetics of anxiety disorders across five continental groups. Through …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology
Our capacity to measure diverse aspects of human biology has developed rapidly in the past
decades, but the rate at which these techniques have generated insights into the biological …
decades, but the rate at which these techniques have generated insights into the biological …
A cross-species proteomic map reveals neoteny of human synapse development
The molecular mechanisms and evolutionary changes accompanying synapse development
are still poorly understood,. Here we generate a cross-species proteomic map of synapse …
are still poorly understood,. Here we generate a cross-species proteomic map of synapse …
An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder
BS Da Silva, EH Grevet, LCF Silva, JKN Ramos… - Discover Mental …, 2023 - Springer
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent psychiatric condition
characterized by developmentally inappropriate symptoms of inattention and/or …
characterized by developmentally inappropriate symptoms of inattention and/or …
Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization
It is unclear whether poverty and mental illness are causally related. Using UK Biobank and
Psychiatric Genomic Consortium data, we examined evidence of causal links between …
Psychiatric Genomic Consortium data, we examined evidence of causal links between …