Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Specialized cells in the body express high levels of V-ATPase in their plasma membrane
and respond to hormonal and nonhormonal cues to regulate extracellular acidification …

Ferroptosis is a novel type of programmed cell death characterized by iron-dependent
accumulation of lipid hydroperoxides to lethal levels. Accumulative studies have indicated …

Scanning ion conductance microscopy (SICM) is a versatile type of scanning probe
microscopy for studies in molecular biology and materials science. Recent advances in …

Adenosine triphosphate (ATP), the universal energy currency of life, has a central role in
numerous biochemical reactions with potential for the synthesis of numerous high-value …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic
kidney disease and is responsible for 5–10% of cases of end-stage renal disease …

The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

Nucleotides are key subunits for nucleic acids and provide energy for intracellular
metabolism. They can also be released from cells to act physiologically as extracellular …

The kidney is a remarkable organ that accomplishes the challenge of removing waste from
the body and simultaneously regulating electrolyte and water balance. Pro-urine flows …

The kidneys are highly metabolic organs that produce vast quantities of adenosine
triphosphate via oxidative phosphorylation and, as such, contain many mitochondria …