Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell
growth in response to nutrient levels. Dysregulation of mTORC1 results in a broad spectrum …

The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine-protein
kinase, which regulates many biological processes related to metabolism, cancer, immune …

Ferroptosis is a novel type of regulated cell death driven by the excessive accumulation of
iron-dependent lipid peroxidation. Therapy-resistant tumor cells, particularly those in the …

O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic post-
translational modification (PTM) involving the covalent binding of serine and/or threonine …

HACE1 is a HECT family E3 ubiquitin–protein ligase with broad but incompletely understood
tumor suppressor activity. Here, we report a previously unrecognized link between HACE1 …

Abstract Yin Yang 1 (YY1) is a key transcription factor that has been implicated in the
development of several malignancies. The stability of YY1 is regulated by the ubiquitin …

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, affecting
millions each year. It emerges from the colon or rectum, parts of the digestive system, and is …

Oncogenic FOXO1 gene fusions drive a subset of rhabdomyosarcoma (RMS) with poor
survival; to date, these cancer drivers are therapeutically intractable. To identify new …