Epidemiology and genetics of granulomatosis with polyangiitis

P Banerjee, A Jain, U Kumar, S Senapati - Rheumatology International, 2021 - Springer
Granulomatosis with polyangiitis (GPA) previously known as Wegener's granulomatosis
(WG) is a rare rheumatic disease affecting subjects of all ages. Prevalence and incidence of …

Updates of ocular involvement in granulomatosis with polyangiitis

L Mei, L Wang, H Yan - Graefe's Archive for Clinical and Experimental …, 2023 - Springer
Granulomatosis with polyangiitis (GPA) is a systemic inflammatory disease characterized by
necrotizing vasculitis of the small-to-medium-sized vessels. GPA results from irregular …

Integrated bioinformatic analysis of the shared molecular mechanisms between ANCA-associated vasculitis and atherosclerosis

X Hu, I Xu Lou, Q Chen - Arthritis Research & Therapy, 2024 - Springer
Background and objective Accumulated evidence supports the tendency of antineutrophil
cytoplasmic antibody (ANCA)-associated vasculitis (AAV) to coexist with atherosclerosis …

Evaluating Single-Nucleotide Polymorphisms in Inflammasome Proteins and Serum Levels of IL-18 and IL-1β in Kidney Interstitial Damage in Anti-Neutrophilic …

L Martinez Valenzuela, A Vidal-Alabró, B Rubio… - International Journal of …, 2024 - mdpi.com
The inflammasome regulates the innate inflammatory response and is involved in
autoimmune diseases. In this study, we explored the levels of IL-18 and IL-1β in serum and …

Meta‐analysis confirmed genetic susceptibility conferred by multiple risk variants from CTLA4 and SERPINA1 in granulomatosis with polyangiitis

P Banerjee, U Kumar, P Khetarpal… - International Journal of …, 2022 - Wiley Online Library
Background Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease.
Smaller sample size and complex nature of the disease pathogenesis has made it …

Unraveling the Immunopathogenesis and genetic variants in Vasculitis toward development of personalized medicine

BJM Yap, AS Lai-Foenander, BH Goh… - Frontiers in …, 2021 - frontiersin.org
Leukocytoclastic vasculitis (LCV) is a systemic autoimmune disease characterized by the
inflammation of the vascular endothelium. Cutaneous small vessel vasculitis (CSVV) and …

Diminished PD-L1 regulation along with dysregulated T lymphocyte subsets and chemokine in ANCA-associated vasculitis

J Singh, RW Minz, B Saikia, R Nada, A Sharma… - Clinical and …, 2023 - Springer
ANCA-associated vasculitis (AAV) is a life-threatening disease characterized by small
vessel inflammation and pathogenic self-directed antibodies. Programmed death-ligand 1 …

Anti-staphylococcal responses and their relationship with HLA-DR-DQ polymorphism in granulomatosis with polyangiitis: a preliminary evidence of association with …

L Rani, J Singh, A Sharma, H Singh, I Verma… - Clinical and …, 2023 - Springer
Chronic nasal carriage of Staphylococcus aureus (S. aureus) is a risk factor for relapse of
granulomatosis with polyangiitis (GPA), and genetic susceptibility to infections and …

HLA sequencing identifies novel associations and suggests clinical relevance of DPB1* 04: 01 in ANCA-associated Granulomatosis with polyangiitis

S Senapati, H Singh, BK Thelma, N Verma, U Kumar - Gene, 2024 - Elsevier
Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease. Major
contributions of HLA genes have been reported; however, HLA typing-based diagnosis or …

Clinical Phenotype and Outcomes of Indo-Asian Patients with ANCA-Associated Glomerulonephritis in the North West, UK

L Floyd, J Storrar, S Pramanik, AD Morris, S Sinha… - Kidney and …, 2023 - mdpi.com
ANCA-associated vasculitides (AAV) are rare, autoimmune conditions associated with end-
stage kidney disease (ESKD) and mortality. Data have predominately been from White …