Research progress of contrast agents for bacterial infection imaging in vivo

Y Zhang, M Hao, L Li, Q Luo, S Deng, Y Yang… - TrAC Trends in …, 2023 - Elsevier
Accurate and sensitive detection of pathogenic bacteria are crucial for effectively treating
bacterial infection and reducing mortality caused by bacterial infection. Contrast agent …

Latest Advances in the Application of Humanized Mouse Model for Staphylococcus aureus

P Zheng, F Liu, J Long, Y Jin, S Chen… - The Journal of …, 2023 - academic.oup.com
Staphylococcus aureus (S. aureus) is an important pathogen for humans and can cause a
wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia …

Fluorescent Antimicrobial Peptides Based on Nile Red: Effect of Conjugation Site and Chemistry on Wash-Free Staining of Bacteria

L Weiss, A Mirloup, L Blondé, H Manko… - Bioconjugate …, 2024 - ACS Publications
Fluorescent probes for bacterial detection can be obtained by conjugating antimicrobial
peptides with fluorescent dyes. However, little is known about the effect of the conjugation …

Bacteria‐Targeted MRI Probe‐Based Imaging Bacterial Infection and Monitoring Antimicrobial Therapy In Vivo

L Li, P Gu, M Hao, X Xiang, Y Feng, X Zhu, Y Song… - Small, 2021 - Wiley Online Library
Despite the significant advances of imaging techniques nowadays, accurate diagnosis of
bacterial infections and real‐time monitoring the efficacy of antibiotic therapy in vivo still …

Enzyme‐Triggered Transforming of Assembly Peptide‐Modified Magnetic Resonance‐Tuned Probe for Highly Sensitive Imaging of Bacterial Infection In Vivo

L Li, M Liu, S Deng, X Zhu, Y Song, E Song - Small, 2023 - Wiley Online Library
Confirming bacterial infection at an early stage and distinguishing between sterile
inflammation and bacterial infection is still highly needed for efficient treatment. Here, in situ …

Longitudinal intravital imaging of the bone marrow for analysis of the race for the surface in a murine osteomyelitis model

C Xie, Y Ren, J Weeks, J Rainbolt… - Journal of …, 2024 - Wiley Online Library
Critical knowledge gaps of orthopedic infections pertain to bacterial colonization. The
established dogma termed the Race for the Surface posits that contaminating bacteria …

Cyclodextrin/adamantane-mediated targeting of inoculated bacteria in mice

MM Welling, N Duszenko, DM van Willigen… - Bioconjugate …, 2021 - ACS Publications
Cyclodextrin (CD)-based host–guest interactions with adamantane (Ad) have demonstrated
use for functionalizing living cells in vitro. The next step in this supramolecular …

Polydispersity-mediated high efficacy of an in-situ aqueous nanosuspension of PPEF. 3HCl in methicillin resistant Staphylococcus aureus sepsis model

AS Lokhande, V Maurya, K Rani, P Parashar… - International Journal of …, 2024 - Elsevier
Abstract Recently, World Health Organization declared antimicrobial resistance as the third
greatest threat to human health. Absence of known cross-resistance, new class, new target …

Interventional nuclear medicine:“click” chemistry as an in vivo targeting strategy for imaging microspheres and bacteria

MM Welling, N Duszenko, DM Van Willigen… - Biomaterials …, 2021 - pubs.rsc.org
Aim: Pre-targeting is a proven strategy for in vivo delivery of a diagnostic or therapeutic
payload. The pre-targeting concept can be realized through various conjugation strategies …

A radio-and fluorescently labelled tracer for imaging and quantification of bacterial infection on orthopaedic prostheses: a proof of principle study

MM Welling, K Warbroek, C Khurshid… - Bone & Joint …, 2023 - boneandjoint.org.uk
Aims Arthroplasty surgery of the knee and hip is performed in two to three million patients
annually. Periprosthetic joint infections occur in 4% of these patients. Debridement …