Structure, dynamics, assembly, and evolution of protein complexes

JA Marsh, SA Teichmann - Annual review of biochemistry, 2015 - annualreviews.org
The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …

Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization

K Hashimoto, H Nishi, S Bryant… - Physical biology, 2011 - iopscience.iop.org
Many soluble and membrane proteins form homooligomeric complexes in a cell which are
responsible for the diversity and specificity of many pathways, may mediate and regulate …

Melatonin attenuates potato late blight by disrupting cell growth, stress tolerance, fungicide susceptibility and homeostasis of gene expression in Phytophthora …

S Zhang, X Zheng, RJ Reiter, S Feng, Y Wang… - Frontiers in plant …, 2017 - frontiersin.org
Phytophthora infestans (P. infestans) is the causal agent of potato late blight, which caused
the devastating Irish Potato Famine during 1845-1852. Until now, potato late blight is still the …

Downregulation of ALDOB is associated with poor prognosis of patients with gastric cancer

J He, Y Jin, Y Chen, HB Yao, YJ Xia, YY Ma… - OncoTargets and …, 2016 - Taylor & Francis
Objectives To examine the expression of ALDOB in gastric cancer (GC) tissue and to reveal
its potential clinicopathological and prognostic significance. Materials and methods We …

Thermal ring-based heat switches in hyperthermophilic class II bacterial fructose aldolase

G Wang - ACS omega, 2023 - ACS Publications
Both thermophilic and hyperthermophilic enzymes in bacterial and archaeal species are
activated above a specific temperature threshold but inactivated at another higher …

The biochemical basis of hereditary fructose intolerance

N Bouteldja, DJ Timson - Journal of inherited metabolic disease, 2010 - Springer
Hereditary fructose intolerance is a rare, but potentially lethal, inherited disorder of fructose
metabolism, caused by mutation of the aldolase B gene. Treatment currently relies solely on …

The emergence of protein complexes: quaternary structure, dynamics and allostery

T Perica, JA Marsh, FL Sousa, E Natan, LJ Colwell… - 2012 - portlandpress.com
All proteins require physical interactions with other proteins in order to perform their
functions. Most of them oligomerize into homomers, and a vast majority of these homomers …

Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution

M Merkulova, A Hurtado-Lorenzo… - … of Physiology-Cell …, 2011 - journals.physiology.org
Previously, we demonstrated that the vacuolar-type H+-ATPase (V-ATPase) a2-subunit
functions as an endosomal pH sensor that interacts with the ADP-ribosylation factor (Arf) …

One-pot biosynthesis of 2-Keto-4-hydroxybutyrate from cheap C1 compounds using rationally designed pyruvate aldolase and methanol dehydrogenase

YJ Jeong, PW Seo, MJ Seo, SB Ju… - Journal of Agricultural …, 2023 - ACS Publications
One-carbon chemicals (C 1s) are potential building blocks as they are cheap, sustainable,
and abiotic components. Methanol-derived formaldehyde can be another versatile building …

The network basis for the structural thermostability and the functional thermoactivity of aldolase B

G Wang - Molecules, 2023 - mdpi.com
Thermostability is important for the thermoactivity of proteins including enzymes. However, it
is still challenging to pinpoint the specific structural factors for different temperature …