MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem
cells into mature red blood cells (RBCs). This process is regulated by several signaling …

Background Multidrug resistance is the main obstacle for hepatocellular carcinoma (HCC)
treatment. miR-32-5p is involved in HCC progression but its function in multidrug resistance …

MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting
protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus …

Abstract Treatment of chronic myelogenous leukemia (CML) with BCR-ABL tyrosine kinase
inhibitors (TKI) fails to eliminate leukemia stem cells (LSC). Patients remain at risk for …

As one of the most common cancers worldwide, colorectal cancer (CRC) causes a large
number of mortality annually. Aberrant expression of microRNAs (miRNAs) is significantly …

Despite historically known as “junk” DNA, nowadays non-coding RNA transcripts (ncRNAs)
are considered as fundamental players in various physiological and pathological conditions …

Background Human erythrocytes are terminally differentiated, anucleate cells long thought
to lack RNAs. However, previous studies have shown the persistence of many small-sized …

Early-stage detection of leukemia is a critical determinant for successful treatment of the
disease and can increase the survival rate of leukemia patients. The factors limiting the …

Self-renewal and differentiation are defining characteristics of hematopoietic stem and
progenitor cells, and their balanced regulation is central to lifelong function of both blood …