Non-Targeted RNA Sequencing: Towards the Development of Universal Clinical Diagnosis Methods for Human and Veterinary Infectious Diseases
Simple Summary With advances in NGS technology, the high ratio of throughput/cost per
base has allowed research laboratories to develop diagnostic protocols that can detect …
base has allowed research laboratories to develop diagnostic protocols that can detect …
Profiling of Microbial Landscape in Lung of Chronic Obstructive Pulmonary Disease Patients Using RNA Sequencing
Purpose The aim of the study was to use RNA sequencing (RNA-seq) data of lung from
chronic obstructive pulmonary disease (COPD) patients to identify the bacteria that are most …
chronic obstructive pulmonary disease (COPD) patients to identify the bacteria that are most …
Single cell transcriptomics reveals the hidden microbiomes of human tissues
G Mahmoudabadi, TS Consortium, SR Quake - bioRxiv, 2022 - biorxiv.org
The human microbiome has been studied extensively across sites in the body that are
readily accessible to sampling. Internal organs and tissues, however, have remained largely …
readily accessible to sampling. Internal organs and tissues, however, have remained largely …
PathoLM: Identifying pathogenicity from the DNA sequence through the Genome Foundation Model
Pathogen identification is pivotal in diagnosing, treating, and preventing diseases, crucial for
controlling infections and safeguarding public health. Traditional alignment-based methods …
controlling infections and safeguarding public health. Traditional alignment-based methods …
[HTML][HTML] Clinical RNA sequencing clarifies variants of uncertain significance identified by prior testing
J Marquez, JN Cech, CR Paschal, B Dingmann… - Genetics in Medicine …, 2024 - Elsevier
Purpose Sequencing-based genetic testing often identifies variants of uncertain significance
(VUS) or fails to detect pathogenic variants altogether. We evaluated the utility of RNA …
(VUS) or fails to detect pathogenic variants altogether. We evaluated the utility of RNA …