Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …

The lysyl oxidase (LOX) family is comprised of LOX and four LOX-like proteins (LOXL1,
LOXL2, LOXL3, and LOXL4), and mainly functions in the remodeling of extracellular matrix …

Maintenance of an appropriate oxygen concentration is essential for the function of the liver.
However, in many pathological conditions, and particularly in the tumor microenvironment …

Objective To summarize the structure, regulatory mechanism, and target genes of hypoxia-
inducible factor-1 alpha (HIF-1α) and to comprehensively expound its role in various chronic …

About 250 million people worldwide are chronically infected with Hepatitis B virus (HBV),
contributing to a large burden on public health. Despite the existence of vaccines and …

The physiological state of the tumor microenvironment (TME) plays a central role in cancer
development due to multiple universal features that transcend heterogeneity and niche …

The hepatitis B virus X protein (HBx) is involved in the process of hepatocellular carcinoma
via the activation of various oncogenes. Our previous study indicated that ARBB1 (arrestin …

Lysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises
five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003 …