Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …

Hematopoiesis is the formation of blood cellular components and, consequently, immune
cells. In a more complete definition, this process refers to the formation, growth, maturation …

Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …

Replicative senescence of cells in vitro is often considered as counterpart for aging of the
organism in vivo. In fact, both processes are associated with functional decay and similar …

Assessment of measurable residual disease (MRD) upon treatment of acute myeloid
leukemia (AML) remains challenging. It is usually addressed by highly sensitive PCR-or …

Epigenetic modifications govern gene expression by guiding the human genome on 'what to
express and what not to'. DNA methyltransferases (DNMTs) establish methylation patterns …

Prostate cancer is the second leading cause of cancer death among men in the United
States. The androgen receptor (AR) antagonist enzalutamide is an FDA-approved drug for …

In mammals, the molecular mechanisms underlying transgenerational inheritance of
phenotypic traits in serial generations of progeny after ancestral environmental exposures …

Background DNA methylation is involved in the epigenetic regulation of gene expression
during developmental processes and is primarily established by the DNA methyltransferase …

Abstract Tatton‐Brown–Rahman syndrome (TBRS) or DNMT3A‐overgrowth syndrome is
characterized by overgrowth and intellectual disability associated with minor dysmorphic …