Hubel and Wiesel began the modern study of development and plasticity of primary visual
cortex (V1), discovering response properties of cortical neurons that distinguished them from …

Early life events can exert a powerful influence on both the pattern of brain architecture and
behavioral development. In this study a conceptual framework is provided for considering …

Vision is the sense humans rely on most to navigate the world, make decisions, and perform
complex tasks. Understanding how humans see thus represents one of the most …

This year, the field of neuroscience celebrates the 50th anniversary of Mountcastle's
discovery of the cortical column. In this review, we summarize half a century of research and …

The cerebral cortex of the human brain is a sheet of about 10 billion neurons divided into
discrete subdivisions or areas that process particular aspects of sensation, movement, and …

Patterns of synaptic connections in the visual system are remarkably precise. These
connections dictate the receptive field properties of individual visual neurons and ultimately …

The cerebral cortex is the largest and most intricately connected part of the mammalian
brain. Its size and complexity has increased during the course of evolution, allowing …

During retinocollicular map development, spontaneous waves of action potentials spread
across the retina, correlating activity among neighboring retinal ganglion cells (RGCs). To …

Highlights•Retinal waves drive visual circuits before the onset of visual experience.•Map
development in the midbrain, thalamus and cortex is regulated by retinal …

Interactions between NMDA receptors (NMDARs) and the PDZ [postsynaptic density-95
(PSD-95)/Discs large/zona occludens-1] domains of PSD-95/SAP90 (synapse-associated …