Adiponectin: Structure, physiological functions, role in diseases, and effects of nutrition

K Khoramipour, K Chamari, AA Hekmatikar, A Ziyaiyan… - Nutrients, 2021 - mdpi.com
Adiponectin (a protein consisting of 244 amino acids and characterized by a molecular
weight of 28 kDa) is a cytokine that is secreted from adipose tissues (adipokine). Available …

Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function

J Frampton, KG Murphy, G Frost, ES Chambers - Nature metabolism, 2020 - nature.com
A key metabolic activity of the gut microbiota is the fermentation of non-digestible
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …

Muscle as a “mediator” of systemic metabolism

KK Baskin, BR Winders, EN Olson - Cell metabolism, 2015 - cell.com
Skeletal and cardiac muscles play key roles in the regulation of systemic energy
homeostasis and display remarkable plasticity in their metabolic responses to caloric …

[HTML][HTML] Adiponectin, driver or passenger on the road to insulin sensitivity?

R Ye, PE Scherer - Molecular metabolism, 2013 - Elsevier
Almost 20 years have passed since the first laboratory evidence emerged that an abundant
message encoding a protein with homology to the C1q superfamily is highly specifically …

Adiponectin and cardiovascular health: an update

X Hui, KSL Lam, PM Vanhoutte… - British journal of …, 2012 - Wiley Online Library
The global epidemic of obesity is accompanied by an increased prevalence of
cardiovascular disease (CVD), in particular stroke and heart attack. Dysfunctional adipose …

The endocannabinoid system and PPARs: Focus on their signalling crosstalk, action and transcriptional regulation

FA Iannotti, RM Vitale - Cells, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …

Role of adiponectin in central nervous system disorders

J Bloemer, PD Pinky, M Govindarajulu, H Hong… - Neural …, 2018 - Wiley Online Library
Adiponectin, the most abundant plasma adipokine, plays an important role in the regulation
of glucose and lipid metabolism. Adiponectin also possesses insulin‐sensitizing, anti …

PPAR-γ and Wnt regulate the differentiation of MSCs into adipocytes and osteoblasts respectively

Y Li, D Jin, W Xie, L Wen, W Chen, J Xu… - Current stem cell …, 2018 - ingentaconnect.com
Background: Under the transcriptional control of numerous factors and intracellular signals,
mesenchymal stem cells (MSCs) can differentiate into various cell types, including …

Adiponectin and energy homeostasis

B Lee, J Shao - Reviews in Endocrine and Metabolic Disorders, 2014 - Springer
White adipose tissue (WAT) is the premier energy depot. Since the discovery of the
hormonal properties of adipose-secreted proteins such as leptin and adiponectin, WAT has …

PPARs and microbiota in skeletal muscle health and wasting

R Manickam, K Duszka, W Wahli - International journal of molecular …, 2020 - mdpi.com
Skeletal muscle is a major metabolic organ that uses mostly glucose and lipids for energy
production and has the capacity to remodel itself in response to exercise and fasting …