Royal jelly: Beneficial properties and synergistic effects with chemotherapeutic drugs with particular emphasis in anticancer strategies
Cancer is one of the major causes of death globally. Currently, various methods are used to
treat cancer, including radiotherapy, surgery, and chemotherapy, all of which have serious …
treat cancer, including radiotherapy, surgery, and chemotherapy, all of which have serious …
Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and …
KJ Szymanska, X Tan, K Oktay - Molecular Human Reproduction, 2020 - academic.oup.com
Among the investigated mechanisms of chemotherapy-induced damage to human
primordial follicle reserve are induction of DNA double-strand breaks (DSBs) and resultant …
primordial follicle reserve are induction of DNA double-strand breaks (DSBs) and resultant …
Anti-Mullerian hormone attenuates both cyclophosphamide-induced damage and PI3K signalling activation, while rapamycin attenuates only PI3K signalling …
R Rosario, HL Stewart, N Spears, EE Telfer… - Human …, 2024 - academic.oup.com
STUDY QUESTION What are the effects of cyclophosphamide exposure on the human ovary
and can anti-Mullerian hormone (AMH) and rapamycin protect against these? SUMMARY …
and can anti-Mullerian hormone (AMH) and rapamycin protect against these? SUMMARY …
TAp63 determines the fate of oocytes against DNA damage
Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target
effect. However, their oocyte death pathway has been debated. Here, we clarified the …
effect. However, their oocyte death pathway has been debated. Here, we clarified the …
Dual suppression of follicle activation pathways completely prevents the cyclophosphamide-induced loss of ovarian reserve
O Kashi, H Roness, I Spector… - Human …, 2023 - academic.oup.com
STUDY QUESTION To what extent and how does combined administration of the follicle
activation pathway suppressive agents temsirolimus (Tem) and c-terminus recombinant anti …
activation pathway suppressive agents temsirolimus (Tem) and c-terminus recombinant anti …
Quercetin prevents primordial follicle loss via suppression of PI3K/Akt/Foxo3a pathway activation in cyclophosphamide-treated mice
J Li, H Long, Y Cong, H Gao, Q Lyu, S Yu… - Reproductive Biology …, 2021 - Springer
Background Chemotherapy improves the survival rates of patients with various cancers but
often causes some adverse effects, including ovarian damage, characterised by a decrease …
often causes some adverse effects, including ovarian damage, characterised by a decrease …
[HTML][HTML] Ovaries of patients recently treated with alkylating agent chemotherapy indicate the presence of acute follicle activation, elucidating its role among other …
D Shai, S Aviel-Ronen, I Spector, H Raanani… - Fertility and sterility, 2021 - Elsevier
Objective To investigate mechanisms of primordial follicle (PMF) loss in vivo in human
ovaries shortly after alkylating agent (AA) chemotherapy. Design Cohort study. Setting …
ovaries shortly after alkylating agent (AA) chemotherapy. Design Cohort study. Setting …
Protective effects and possible mechanisms of actions of Bushen Cuyun recipe on diminished ovarian reserve induced by cyclophosphamide in rats
M Jiang, W Wang, J Zhang, C Wang, Y Bi… - Frontiers in …, 2020 - frontiersin.org
Backgrounds Diminished ovarian reserve (DOR) contributes significantly to female infertility.
Bushen Cuyun Recipe (BCR, Tradename Yueliang Yin), a product marketed in China, has …
Bushen Cuyun Recipe (BCR, Tradename Yueliang Yin), a product marketed in China, has …
Overactivation or Apoptosis: Which Mechanisms Affect Chemotherapy-Induced Ovarian Reserve Depletion?
O Kashi, D Meirow - International Journal of Molecular Sciences, 2023 - mdpi.com
Dormant primordial follicles (PMF), which constitute the ovarian reserve, are recruited
continuously into the cohort of growing follicles in the ovary throughout female reproductive …
continuously into the cohort of growing follicles in the ovary throughout female reproductive …
Protective effects of antioxidants on cyclophosphamide-induced ovarian toxicity
RS Barberino, RLS Silva… - Biopreservation and …, 2023 - liebertpub.com
The most common limitation of anticancer chemotherapy is the injury to normal cells.
Cyclophosphamide, which is one of the most widely used alkylating agents, can cause …
Cyclophosphamide, which is one of the most widely used alkylating agents, can cause …