Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the
skin, and the immune system. Histaminergic neurons in mammalian brain are located …

Traumatic brain injury (TBI) is a devastating disease, predominantely affecting young
people. Although the prognosis for TBI victims has improved in recent years, many survivors …

Apart from its central role in the mediation of allergic reactions, gastric acid secretion and
inflammation in the periphery, histamine serves an important function as a neurotransmitter …

Publisher Summary This chapter focuses on brain edema formation in heat stress and its
contribution to cell injury. In addition, the basic concepts of brain edema formation, including …

The blood–brain barrier minimizes the entry of molecules into brain tissue. This restriction
arises by the presence of tight junctions (zonulae occludens) between adjacent endothelial …

The cerebral endothelium represents an active interface between blood and central nervous
system. The blood-brain barrier restricts the free passage of nutrients, hormones, drugs and …

The effect of histamine on blood-brain barrier permeability was investigated using in situ
measurement of transendothelial electrical resistance in brain-surface microvessels of …

Cerebrolysin is a peptide mixture able to ameliorate symptomatology and delay progression
of neurological disorders such as Alzheimer's disease and dementia. The administration of …

Several neurotrophic factors are known to induce neuroprotection in traumatic injuries to the
central nervous system (CNS). However, many neurotrophins are unable to attenuate cell …

The blood-brain barrier (BBB) which is located in the continuous endothelial lining of
cerebral blood vessels rigidly controls exchange of water soluble compounds under …