Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed
cerebral ischemia (DCI) is one of the most important causes of mortality and poor …

Subarachnoid haemorrhage (SAH) is a form of stroke that is associated with substantial
morbidity, often as a result of cerebral ischaemia that occurs in the following days. These …

Cerebral autoregulation (CA) is a protective mechanism that maintains cerebral blood flow
at a relatively constant level despite fluctuations of cerebral perfusion pressure or arterial …

Pressure autoregulation is an important hemodynamic mechanism that protects the brain
against inappropriate fluctuations in cerebral blood flow in the face of changing cerebral …

Background Guidelines recommend cerebral perfusion pressure (CPP) values of 50–70
mmHg and intracranial pressure lower than 20 mmHg for the management of acute …

There are occasionally intraoperative circumstances in which reduction of mean arterial
pressure (MAP) to levels well below those that occur in nonanesthetized adults is necessary …

Background High intracranial pressure (ICP) and low cerebral perfusion pressure (CPP)
may induce secondary brain injury following aneurysmal subarachnoid hemorrhage (aSAH) …

Background and Purpose—The purpose of this study was to investigate the relationship
between cerebrovascular autoregulation and outcome after aneurysmal subarachnoid …

Measurement of intracranial pressure (ICP) and mean arterial pressure (MAP) is used to
derive cerebral perfusion pressure (CPP) and to guide targeted therapy of acute brain injury …