Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify
preclinical individuals and target potentially disease-modifying therapies towards them …

Background: Spatial navigation is the ability to estimate one's position on the basis of
environmental and self-motion cues. Spatial memory is the cognitive substrate underlying …

The hippocampus is regarded as the pivotal structure for episodic memory symptoms
associated with Alzheimer's disease (AD) pathophysiology. However, what is often …

Alzheimer's disease (AD) or vestibular dysfunction may impair visual–spatial cognitive
function. Recent studies have shown that vestibular dysfunction is increasingly common in …

(1) Background: Spatial cognition (SC) is one of the earliest cognitive domains to be
impaired in the course of Alzheimer's disease (AD), resulting in spatial disorientation and …

Objective: Spatial disorientation is common in Alzheimer's disease (AD), Mild Cognitive
Impairment (MCI), and preclinical individuals with AD biomarkers. However, traditional …

Purpose Identification of demographic, physical/physiological, lifestyle and genetic factors
contributing to the onset of dementia, specifically Alzheimer disease (AD), and …

Introduction: An active lifestyle may protect older adults from cognitive decline. Yet, due to
the complex nature of outdoor environments, many people living with dementia experience …

Spatial navigation critically underlies hippocampal-entorhinal circuit function that is early
affected in Alzheimer's disease (AD). There is growing evidence that AD pathophysiology …

Introduction Cognitive complaints in older adults may be indicative of progressive cognitive
decline including Alzheimer's disease (AD), but also occur in other age-related chronic …