Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

This article provides an overview of neuroimaging biomarkers in experimental
epileptogenesis and refractory epilepsy. Neuroimaging represents a gold standard and …

Brain inflammation is a major factor in epilepsy, and the high mobility group box-1 (HMGB1)
protein is known to contribute significantly to the generation of seizures. Here, we …

Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the
most common types of medically refractory epilepsy. Deep brain stimulation (DBS) shows …

Objective Drug‐resistant epilepsy causes great clinical danger and still lacks effective
treatments. Methods Here, we used multifaceted approaches combining electrophysiology …

Epilepsy is a circuit-level brain disorder characterized by excessive or hypersynchronous
epileptic seizures involving a complex epileptogenic network. Cumulative evidence …

Previously, we developed electroresponsive hydrogel nanoparticles (ERHNPs) modified
with angiopep-2 (ANG) to facilitate the delivery of the antiseizure drug phenytoin sodium …

High-frequency stimulation (HFS) of the anterior nucleus of thalamus (ANT) is a new and
alternative option for the treatment of intractable epilepsy. However, the responder rate is …

Brain stimulation is an alternative treatment for epilepsy. However, the neuronal circuits
underlying its mechanisms remain obscure. We found that optogenetic activation (1Hz) of …

Although the piriform cortex (PC) has been previously implicated as a critical node for
seizure generation and propagation, the underlying neural mechanism has remained …