The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

The epithelial surfaces of the lungs are in direct contact with the environment and are
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …

The pre-metastatic niche educated by primary tumor-derived elements contributes to cancer
metastasis. However, the role of host stromal cells in metastatic niche formation and organ …

The lung is continuously exposed to particles, toxicants, and microbial pathogens that are
cleared by a complex mechanical, innate, and acquired immune system. Mucociliary …

Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

The clinical manifestations of asthma are caused by obstruction of the conducting airways of
the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and …

Idiopathic pulmonary fibrosis (IPF) is an incurable complex genetic disorder that is
associated with sequence changes in 7 genes (MUC5B, TERT, TERC, RTEL1, PARN …

The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus
obstruction of the airways. To further investigate this incompletely understood pathobiology …

Many organs throughout the body maintain epithelial homeostasis by employing a mucosal
barrier which acts as a lubricant and helps to preserve a near-sterile epithelium. Goblet cells …