Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands
G Qin, Z Liu, J Yang, X Liao, C Zhao, J Ren, X Qu - Nature Cell Biology, 2024 - nature.com
Despite the demonstrated importance of DNA G-quadruplexes (G4s) in health and disease,
technologies to readily manipulate specific G4 folding for functional analysis and therapeutic …
technologies to readily manipulate specific G4 folding for functional analysis and therapeutic …
Z-DNA at the crossroads: untangling its role in genome dynamics
VJ Sahayasheela, M Ooga, T Kumagai… - Trends in Biochemical …, 2025 - cell.com
DNA can fold into noncanonical left-handed Z-DNA conformation beyond the right-handed B-
DNA. While its crystal structure was discovered nearly four decades ago, it was …
DNA. While its crystal structure was discovered nearly four decades ago, it was …
Advancing Sustainable Peptide Synthesis by Solvent Quality Control: Understanding and Mitigating Hydroperoxide in 1-Butyl-2-pyrrolidinone (NBP)
J Pawlas, TM El-Dine, K Bargen, C Bargen… - … Process Research & …, 2024 - ACS Publications
While numerous studies aimed at producing peptides in a sustainable manner have recently
been reported, the impact of the quality of starting materials on sustainability in peptide …
been reported, the impact of the quality of starting materials on sustainability in peptide …
Dimeric-molecular beacon based intramolecular strand displacement amplification enables robust analysis of miRNA
G Xue, Z Sui, B Chen, Z Xiao, Y Yao, L Hua, J Xu - Talanta, 2024 - Elsevier
Given the critical role of miRNAs in regulating gene expression and their potential as
biomarkers for various diseases, accurate and sensitive miRNA detection is essential for …
biomarkers for various diseases, accurate and sensitive miRNA detection is essential for …