Overview of the blood biomarkers in Alzheimer's disease: promises and challenges

C Delaby, C Hirtz, S Lehmann - Revue Neurologique, 2023 - Elsevier
The increasing number of people with advanced Alzheimer's disease (AD) represents a
significant psychological and financial cost to the world population. Accurate detection of the …

A critical appraisal of blood-based biomarkers for Alzheimer's disease

S Lista, M Mapstone, F Caraci, E Emanuele… - Ageing Research …, 2024 - Elsevier
Biomarkers that predict the clinical onset of Alzheimer's disease (AD) enable the
identification of individuals in the early, preclinical stages of the disease. Detecting AD at this …

Relationship between topological efficiency of white matter structural connectome and plasma biomarkers across the Alzheimer's disease continuum

M Zhang, H Chen, W Huang, T Guo, G Ma… - Human Brain …, 2024 - Wiley Online Library
Both plasma biomarkers and brain network topology have shown great potential in the early
diagnosis of Alzheimer's disease (AD). However, the specific associations between plasma …

Neurofilaments Light Chain in Neurodegenerative Dementias: A Review of Imaging Correlates

C Gallingani, C Carbone, M Tondelli, G Zamboni - Brain Sciences, 2024 - mdpi.com
Neurofilaments light chain (NfLs) are currently recognized as a marker of axonal injury and
degeneration. Their measurement in biological fluids has a promising role in the diagnosis …

White matter dementia then… and now

CM Filley - Frontiers in Neurology, 2022 - frontiersin.org
White matter dementia (WMD) is a concept introduced in 1988 to highlight the importance of
white matter pathology in producing cognitive dysfunction and dementia. Whereas gray …

Potential role of blood pressure variability and plasma neurofilament light in the mechanism of comorbidity between Alzheimer's disease and cerebral small vessel …

Q Li, S Su, Y Feng, M Jia, J Zhan, Z Liao… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Long‐term blood pressure variability (BPV) and plasma neurofilament light
(pNfL) have been identified as potential biomarkers for Alzheimer's disease (AD) and …

[HTML][HTML] Elevated plasma neurofilament light was associated with multi-modal neuroimaging features in Alzheimer's Disease signature regions and predicted future …

Q Hu, M Shi, Y Li, X Zhao - Research Square, 2024 - ncbi.nlm.nih.gov
Background: Neurofilament Light (NfL) is a biomarker for early neurodegeneration in
Alzheimer's disease (AD). This study aims to examine the association between plasma NfL …

Axonal degeneration serum markers and temporal lobe atrophy in Alzheimer dementia continuum: a longitudinal study of plasma neurofilament light and tensor-based …

A Khodadadi, N Amirkhani, Z Nouri, T Adlparvar… - medRxiv, 2024 - medrxiv.org
The plasma neurofilament light chain (NfL), an axonal cytoskeleton protein, increases in
Alzheimer disease and was therefore proposed as a blood-based biomarker of the disease …

Diffusion tensor imaging (DTI) and plasma p-tau 181 in Alzheimer's disease

F Nabizadeh, SB Jameie - Neurology Letters, 2022 - neurologyletters.com
Alzheimer's Disease (AD) is characterized by cognitive impairments and memory difficulties,
which cause daily activities, and personal and behavioral problems. In recent years blood …

Berberina: aspectos químicos, farmacológicos e sua potencial relação profilática com a doença de Alzheimer

SR do Nascimento Freitas, TF da Silva… - Research, Society and …, 2023 - rsdjournal.org
This article aimed to review the chemical and pharmacological aspects of berberine,
correlating them with the pathophysiological outcome of Alzheimer's disease (AD). A …