The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

The centrosome, a key microtubule organizing centre, is composed of centrioles, embedded
in a protein-rich matrix. Centrosomes control the internal spatial organization of somatic …

Mutations in several genes encoding centrosomal proteins dramatically decrease the size of
the human brain. We show that Aspm (abnormal spindle-like, microcephaly-associated) and …

Microcephaly or reduced head circumference results from a multitude of abnormal
developmental processes affecting brain growth and/or leading to brain atrophy. Autosomal …

Human genetic studies have established a link between a class of centrosome proteins and
microcephaly. Current studies of microcephaly focus on defective centrosome/spindle …

Microtubules are polarized intracellular polymers that play key roles in the cell, including in
transport, polarity, and cell division. Across eukaryotic cell types, microtubules adopt diverse …

Autosomal recessive primary microcephaly (MCPH) is a rare hereditary
neurodevelopmental disorder characterized by a marked reduction in brain size and …

Several genes expressed at the centrosome or spindle pole have been reported to underlie
autosomal recessive primary microcephaly (MCPH), a neurodevelopmental disorder …