Potential of Essential Oil-Based Anticholinesterase Insecticides against Anopheles Vectors: A Review

TA Rants'o, LL Koekemoer, JL Panayides, RL van Zyl - Molecules, 2022 - mdpi.com
The insect nervous system is critical for its functional integrity. The cholinergic system, of
which acetylcholinesterase (AChE) is a key enzyme, is essential to the Anopheles …

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

EO Adedeji, OO Ogunlana, S Fatumo, T Beder… - Parasites & vectors, 2020 - Springer
The increasing resistance to currently available insecticides in the malaria vector,
Anopheles mosquitoes, hampers their use as an effective vector control strategy for the …

Potential inhibitors of the enzyme acetylcholinesterase and juvenile hormone with insecticidal activity: Study of the binding mode via docking and molecular dynamics …

RS Ramos, WJC Macêdo, JS Costa… - Journal of …, 2020 - Taylor & Francis
Abstract Models validation in QSAR, pharmacophore, docking and others can ensure the
accuracy and reliability of future predictions in design and selection of molecules with …

Identification of potential inhibitors from pyriproxyfen with insecticidal activity by virtual screening

R da Silva Ramos, J da Silva Costa, R Campos Silva… - Pharmaceuticals, 2019 - mdpi.com
Aedes aegypti is the main vector of dengue fever transmission, yellow fever, Zika, and
chikungunya in tropical and subtropical regions and it is considered to cause health risks to …

Enzyme Dynamics Determine the Potency and Selectivity of Inhibitors Targeting Disease-Transmitting Mosquitoes

R Kumari, C Lindgren, R Kumar, N Forsgren… - ACS Infectious …, 2024 - ACS Publications
Vector control of mosquitoes with insecticides is an important tool for preventing the spread
of mosquito-borne diseases including malaria, dengue, chikungunya, and Zika …

Larvicidal activity and in silico studies of cinnamic acid derivatives against Aedes aegypti (Diptera: Culicidae)

SB França, LCB de Lima, CR da Silva Cunha… - Bioorganic & Medicinal …, 2021 - Elsevier
Cinnamic acid derivatives (CAD's) represent a great alternative in the search for insecticides
against Aedes aegypti mosquitoes since they have antimicrobial and insecticide properties …

Larvicidal Activity of Constituents from the Main Brazilian Propolis Types: Green, Red, and Brown against Aedes aegypti

VP Ribeiro, JK Bastos, AS Estep, KM Meepagala - ACS omega, 2024 - ACS Publications
In search of environmentally benign and mammalian-friendly mosquito-mitigating
compounds, we conducted an investigation into the constituents isolated from Brazilian red …

Uncovering the genetic diversity in Aedes aegypti insecticide resistance genes through global comparative genomics

A Spadar, E Collins, LA Messenger, TG Clark… - Scientific Reports, 2024 - nature.com
Aedes aegypti is vector of many arboviruses including Zika, dengue, yellow fever, West Nile,
and Chikungunya. Its control efforts are hampered by widespread insecticide resistance …

[HTML][HTML] Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae

Q Han, DM Wong, H Robinson, H Ding, PCH Lam… - Insect …, 2018 - ncbi.nlm.nih.gov
Organophosphates and carbamates represent two major classes of AChE inhibitors used as
insecticides in agriculture and public health. Mosquitoes carry two AChE genes, ace-1 and …

Structure–Activity Relationships Reveal Beneficial Selectivity Profiles of Inhibitors Targeting Acetylcholinesterase of Disease-Transmitting Mosquitoes

A Vidal-Albalat, T Kindahl, R Rajeshwari… - Journal of Medicinal …, 2023 - ACS Publications
Insecticide resistance jeopardizes the prevention of infectious diseases such as malaria and
dengue fever by vector control of disease-transmitting mosquitoes. Effective new insecticidal …